Sedative and cardiorespiratory effects of dexmedetomidine alone or combined with acepromazine in healthy cats

The purpose of this study was to assess sedation, emesis and cardiovascular effects of dexmedetomidine alone or combined with acepromazine in healthy cats. Fourteen male cats aged 0.9 ± 0.5 years and weighing 3.7 ± 0.7 kg were randomly assigned to one of two experimental groups: GD, dexmedetomidine...

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Bibliographic Details
Published in:The veterinary journal (1997) 2024-04, Vol.304, p.106099-106099, Article 106099
Main Authors: Schimites, P.I., Mangini, L.T., Gasparotto, J.C., Franco, I.G., Alves, T.S., Biaggio, M.L., Mangini, N.P., Freitas, G.C., Floriano, B.P., Soares, A.V.
Format: Article
Language:English
Subjects:
Acepromazine - pharmacology
Alpha2- agonist
Anesthesia - veterinary
Animals
Antiemetic
Cat
Cats
Dexmedetomidine - pharmacology
Hypnotics and Sedatives - pharmacology
Male
Phenothiazine
Sedation
Vomiting - veterinary
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Summary:The purpose of this study was to assess sedation, emesis and cardiovascular effects of dexmedetomidine alone or combined with acepromazine in healthy cats. Fourteen male cats aged 0.9 ± 0.5 years and weighing 3.7 ± 0.7 kg were randomly assigned to one of two experimental groups: GD, dexmedetomidine 5 µg/kg; and GDA, dexmedetomidine 5 µg/kg with acepromazine 0.03 mg/kg, all intramuscularly. Measurements were recorded at baseline, at 20 minutes and then at 10–minute intervals following sedation and included heart rate (HR), respiratory rate (FR), systolic arterial pressure (SAP), rectal temperature (RT), number of episodes of emesis and sedation score (0–4). Data were compared using ANOVA for repeated measures followed by Šídák and Dunnet test. Sedation scores were compared between groups at T20 using Mann-Whitney test. Significance was considered when P
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2024.106099