Combined microfocused ultrasound and delicate pulsed light for facial rejuvenation: A prospective, randomized, and split-face study

• Published in: Lasers in surgery and medicine 2024-04, Vol.56 (4), p.346-354
• Main Authors: Wang, Yawen, Liang, Jingchen, Chen, Ying, Xia, Jun, Liu, Yanting, Liu, Jing, Li, Youbao, Yang, Mengyao, Wang, Zhao, Zeng, Weihui
• Format: Article
• Language: English
• Subjects: Combined treatment; Effectiveness; Elasticity; Erythema; Face; Melanin; Side effects; Skin; Ultrasonic imaging; Ultrasound; Water loss
• ISSN: 0196-8092; 1096-9101; 1096-9101
• DOI: 10.1002/lsm.23777

Public's interest in noninvasive skin rejuvenation treatments continues to grow. The advantage of combination therapy lies in that it can target different aspects of skin rejuvenation. This study aimed to assess the efficacy and safety of microfocused ultrasound (MFU) combined with delicate pulsed light (DPL) for facial rejuvenation. Twenty-one patients with facial relaxation were enrolled. All patients received whole-face MFU treatment, and one side of the face was randomly assigned to receive DPL. MFU treatment was performed at Months 0 and 3, while DPL treatment was performed at Months 1, 2, 4, and 5. The length and angle of the nasolabial fold and perioral wrinkles, melanin index (MI), erythema index (EI), transepidermal water loss (TEWL), and follow-up time were recorded at Months 0, 3, and 6. Side effects were recorded during treatment and each follow-up visit. Twenty patients successfully completed the study. At the sixth month, the average length of perioral wrinkles and nasolabial folds on the combined side decreased by 11.5% (p