Implications of tricuspid regurgitation and right ventricular volume overload in patients with heart failure with preserved ejection fraction

Aims The aim of this study was to assess the pathophysiological implications of severe tricuspid regurgitation (TR) in patients with heart failure with preserved ejection fraction (HFpEF) by using tricuspid transcatheter edge‐to‐edge repair (T‐TEER) as a model of right ventricular (RV) volume overlo...

Full description

Saved in:
Bibliographic Details
Published in:European journal of heart failure 2024-04, Vol.26 (4), p.1025-1035
Main Authors: Kresoja, Karl‐Patrik, Rosch, Sebastian, Schöber, Anne Rebecca, Fengler, Karl, Schlotter, Florian, Bombace, Sara, Sagmeister, Paula, Roeder, Maximilian, Kister, Tobias, Gutberlet, Matthias, Thiele, Holger, Rommel, Karl‐Philipp, Lurz, Philipp
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cardiac Catheterization - methods
Cardiac magnetic resonance imaging
Diastole
Female
Heart Failure - complications
Heart Failure - physiopathology
Heart failure with preserved ejection fraction
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Magnetic Resonance Imaging, Cine - methods
Male
Prospective Studies
Stroke Volume - physiology
Transcatheter tricuspid valve repair
Tricuspid regurgitation
Tricuspid Valve Insufficiency - complications
Tricuspid Valve Insufficiency - physiopathology
Ventricular Dysfunction, Right - physiopathology
Ventricular Function, Left - physiology
Ventricular Function, Right - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims The aim of this study was to assess the pathophysiological implications of severe tricuspid regurgitation (TR) in patients with heart failure with preserved ejection fraction (HFpEF) by using tricuspid transcatheter edge‐to‐edge repair (T‐TEER) as a model of right ventricular (RV) volume overload relief. Methods and results This prospective interventional single arm trial (NCT04782908) included patients with invasively diagnosed HFpEF. The following parameters were prospectively assessed before and after T‐TEER: left ventricular (LV) diastolic properties by invasive pressure–volume loop recordings; biventricular time–volume curves and function as well as septal curvature by cardiac magnetic resonance imaging; strain analyses for timing of septal motion. Overall, 20 patients (median age 78, interquartile range [IQR] 72–83 years, 65% female) were included. T‐TEER reduced TR by a median of 2 (of 5) grades (IQR 2–1). T‐TEER increased LV stroke volume and LV end‐diastolic volume (LVEDV) (p 
ISSN:1388-9842
1879-0844
1879-0844
DOI:10.1002/ejhf.3195