Triterpenoids from Juglans mandshurica with anti-hyaluronidase activities

Phytochemical study on 90% ethanol extract from the green walnut husks of Juglans mandshurica Maxim. resulted into the isolation of three undescribed triterpenoids, juglansmanoids A-C (1-3). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D ( 1 H- 1 H C...

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Bibliographic Details
Published in:Journal of asian natural products research 2024-07, Vol.26 (7), p.773-779
Main Authors: Qi, Ze-Chen, Chen, Qiu-Han, Xu, Zeng, Yang, Chen
Format: Article
Language:English
Subjects:
anti-hyaluronidase activities
Ethanol
Juglandaceae
Juglans mandshurica
Magnetic resonance spectroscopy
Mass spectrometry
Mass spectroscopy
NMR spectroscopy
Oleanolic acid
Spectral methods
Triterpenoids
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Summary:Phytochemical study on 90% ethanol extract from the green walnut husks of Juglans mandshurica Maxim. resulted into the isolation of three undescribed triterpenoids, juglansmanoids A-C (1-3). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D ( 1 H- 1 H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated components were evaluated in vitro for anti-hyaluronidase activities. As a result, triterpenoid 1 exhibited potent anti-hyaluronidase activity (IC 50 = 9.78 μg/ml) three times more than the positive control drug oleanolic acid (IC 50 = 40.12 μg/ml).
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2024.2327514