Survival outcomes and treatment experience of 124 patients with primary central nervous system lymphoma

Purpose Primary central nervous system lymphoma (PCNSL) is a rare malignancy of the central nervous system with high invasiveness. There is little consensus on the treatment of PCNSL. This study retrospectively studied data from PCNSL patients in a single center to summarize treatment experience and...

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Bibliographic Details
Published in:Strahlentherapie und Onkologie 2024-09, Vol.200 (9), p.760-773
Main Authors: Tang, Ziqing, Wu, Geting, Tan, Fang, Long, Yang, Hong, Jidong, Lyu, Zhiping, Wei, Rui
Format: Article
Language:English
Subjects:
Central nervous system
Cerebrospinal fluid
Induction therapy
Lactate dehydrogenase
Lactic acid
Lymphocytes
Lymphoma
Medical prognosis
Medicine
Medicine & Public Health
Multivariate analysis
Nervous system
Oncology
Original Article
Radiotherapy
Survival
Therapy
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Summary:Purpose Primary central nervous system lymphoma (PCNSL) is a rare malignancy of the central nervous system with high invasiveness. There is little consensus on the treatment of PCNSL. This study retrospectively studied data from PCNSL patients in a single center to summarize treatment experience and explore prognostic factors. Methods Survival curves were drawn using the Kaplan–Meier method and prognostic factors were analyzed using Cox’s hazards model. Results In multivariate analysis, cerebrospinal fluid lactic acid dehydrogenase (CSF LDH; p  = 0.005 and p  = 0.002), neutrophil to lymphocyte ratio (NLR; p  = 0.014 and p  = 0.038), and completion of four cycles of induction therapy ( p  
ISSN:0179-7158
1439-099X
1439-099X
DOI:10.1007/s00066-024-02219-5