Green nanotech paradigm for enhancing sesquiterpene lactone therapeutics in cancer

In the field of cancer therapy, sesquiterpene lactones (SLs) derived from diverse Dicoma species demonstrate noteworthy bioactivity. However, the translation of their full therapeutic potential into clinical applications encounters significant challenges, primarily related to solubility, bioavailabi...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2024-04, Vol.173, p.116426-116426, Article 116426
Main Authors: Zahra, Mehak, Abrahamse, Heidi, George, Blassan P.
Format: Article
Language:English
Subjects:
Anticancer therapy
Bioactive compounds
Dicoma species
Green nanotechnology
Sesquiterpene lactones
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Summary:In the field of cancer therapy, sesquiterpene lactones (SLs) derived from diverse Dicoma species demonstrate noteworthy bioactivity. However, the translation of their full therapeutic potential into clinical applications encounters significant challenges, primarily related to solubility, bioavailability, and precise drug targeting. Despite these obstacles, our comprehensive review introduces an innovative paradigm shift that integrates the inherent therapeutic properties of SLs with the principles of green nanotechnology. To overcome issues of solubility, bioavailability, and targeted drug delivery, eco-friendly strategies are proposed for synthesizing nanocarriers. Green nanotechnology has emerged as a focal point in addressing environmental and health concerns linked to conventional treatments. This progressive approach of green nanotechnology holds promise for the development of safe and sustainable nanomaterials, particularly in the field of drug delivery. This groundbreaking methodology signifies a pioneering advancement in the creation of novel and effective anticancer therapeutics. It holds substantial potential for transforming cancer treatment and advancing the landscape of natural product research. [Display omitted] •Sesquiterpenes from Dicoma species demonstrate significant anticancer activities.•Sesquiterpenes are promising candidates for therapeutic development.•Nanotechnology with SLs holds promise for potent anticancer treatments.•SLs solubility, bioavailability, targeted drug delivery challenges to be addressed.•Ecofriendly strategies for synthesizing nanocarriers and sustainable drug delivery.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2024.116426