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On‐Demand Bioactivation of Inert Materials With Plasma‐Polymerized Nanoparticles

Conventional gas plasma treatments are crucial for functionalizing materials in biomedical applications, but have limitations hindering their broader use. These methods require exposure to reactive media under vacuum conditions, rendering them unsuitable for substrates that demand aqueous environmen...

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Published in:Advanced materials (Weinheim) 2024-09, Vol.36 (38), p.e2311313-n/a
Main Authors: Santos, Miguel, Michael, Praveesuda L., Mitchell, Timothy C., Lam, Yuen Ting, Robinson, Thomas M., Moore, Mathew J., Tan, Richard P., Rnjak‐Kovacina, Jelena, Lim, Khoon S., Wise, Steven G.
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container_issue 38
container_start_page e2311313
container_title Advanced materials (Weinheim)
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creator Santos, Miguel
Michael, Praveesuda L.
Mitchell, Timothy C.
Lam, Yuen Ting
Robinson, Thomas M.
Moore, Mathew J.
Tan, Richard P.
Rnjak‐Kovacina, Jelena
Lim, Khoon S.
Wise, Steven G.
description Conventional gas plasma treatments are crucial for functionalizing materials in biomedical applications, but have limitations hindering their broader use. These methods require exposure to reactive media under vacuum conditions, rendering them unsuitable for substrates that demand aqueous environments, such as proteins and hydrogels. In addition, complex geometries are difficult to treat, necessitating extensive customization for each material and shape. To address these constraints, an innovative approach employing plasma polymer nanoparticles (PPN) as a versatile functionalization tool is proposed. PPN share similarities with traditional plasma polymer coatings (PPC) but offer unique advantages: compatibility with aqueous systems, the ability to modify complex geometries, and availability as off‐the‐shelf products. Robust immobilization of PPN on various substrates, including synthetic polymers, proteins, and complex hydrogel structures is demonstrated in this study. This results in substantial improvements in surface hydrophilicity. Materials functionalization with arginylglycylaspartic acid (RGD)‐loaded PPN significantly enhances cell attachment, spreading, and substrate coverage on inert scaffolds compared to passive RGD coatings. Improved adhesion to complex geometries and subsequent differentiation following growth factor exposure is also demonstrated. This research introduces a novel substrate functionalization approach that mimics the outcomes of plasma coating technology but vastly expands its applicability, promising advancements in biomedical materials and devices. Conventional gas plasma treatments can significantly improve material properties for biomedical applications but are not applicable to important substrate classes such as proteins and hydrogels. Plasma polymer nanoparticles (PPN) are versatile functionalization tools compatible with aqueous systems, able to modify complex geometries that mimic the outcomes of plasma coating technology, but vastly expanding its applicability.
doi_str_mv 10.1002/adma.202311313
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subjects Animals
Aqueous environments
Biocompatibility
Biomedical materials
Cell Adhesion - drug effects
Gas plasmas
Growth factors
Humans
Hydrogels
Hydrogels - chemistry
Hydrophobic and Hydrophilic Interactions
Mice
Nanoparticles
Nanoparticles - chemistry
nanotechnology
Oligopeptides - chemistry
Plasma
Plasma Gases - chemistry
plasma polymerized nanoparticles
Polymer coatings
Polymerization
Polymers
Polymers - chemistry
Proteins
scaffold functionalization
Substrates
Surface Properties
tissue engineering
title On‐Demand Bioactivation of Inert Materials With Plasma‐Polymerized Nanoparticles
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