Polymorphism in Genes Encoding Adaptor Proteins ST13 and STIP1 and the Risk of Ischemic Stroke: a Pilot Study

Adaptor proteins stress induced phosphoprotein 1 (STIP1) and ST13 Hsp70 interacting protein (ST13) may play a crucial role in the pathophysiology of ischemic stroke through controlling protein folding, neuronal survival, and regulation of HSP70/HSP90. The present pilot study investigated whether tag...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2024-02, Vol.176 (4), p.477-480
Main Authors: Stetskaya, T. A., Krapiva, A. B., Kobzeva, K. A., Gurtovoy, D. E., Komkova, G. V., Polonikov, A. V., Bushueva, O. Yu
Format: Article
Language:English
Subjects:
Adaptor proteins
Antihypertensives
Atherosclerosis
Biology
Biomedical and Life Sciences
Biomedicine
Blood vessels
Brain research
Cell Biology
Cerebrovascular disease
Cytokines
Epidemiology
Female
Females
Gene expression
Gene polymorphism
Genetic markers
Genetic testing
Genetics
Genotype
Haplotypes
Heat shock proteins
Heat-Shock Proteins - genetics
HSP70 Heat-Shock Proteins - metabolism
Hsp70 protein
Hsp90 protein
Humans
Internal Medicine
Ischemia
Ischemic Stroke
Laboratory Medicine
Molecular Chaperones - genetics
Pathology
Pilot Projects
Polymorphism
Polymorphism, Genetic
Protein folding
Stroke
Tumor Suppressor Proteins - genetics
Vein & artery diseases
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Summary:Adaptor proteins stress induced phosphoprotein 1 (STIP1) and ST13 Hsp70 interacting protein (ST13) may play a crucial role in the pathophysiology of ischemic stroke through controlling protein folding, neuronal survival, and regulation of HSP70/HSP90. The present pilot study investigated whether tagSNPs in genes encoding ST13 ( rs138335 , rs138344 , rs7290793 , and rs138344 ) and STIP1 ( rs4980524 ) are associated with ischemic stroke. DNA samples from 721 ischemic stroke patients and 471 healthy controls were genotyped using the MassArray-4. Our research revealed a relationship between rs138344 ST13 and the risk of ischemic stroke, which was seen only in females (risk allele G ; OR=1.34, 95%CI=1.07-1.69; p =0.01). The haplotype rs138335G - rs138344C - rs7290793C ST13 was linked with lower risk of ischemic stroke in females: OR=0.42; 95%CI=0.26-0.68; p =0.0005. Thus, ST13 represents a novel genetic marker for ischemic stroke.
ISSN:0007-4888
1573-8221
1573-8221
DOI:10.1007/s10517-024-06050-x