Childhood adversity is associated with anxiety and depression in older adults: A cumulative risk and latent class analysis

• Published in: Journal of affective disorders 2024-06, Vol.354, p.181-190
• Main Authors: Lian, James, Kiely, Kim M., Callaghan, Bridget L., Anstey, Kaarin J.
• Format: Article
• Language: English
• Subjects: ACEs; Adverse childhood experiences; Anxiety; Depression; GAM; LCA
• ISSN: 0165-0327; 1573-2517
• DOI: 10.1016/j.jad.2024.03.016

The long-lasting influence of childhood adversity on mental health is well documented; however empirical research examining how this association extends into older adults is limited. This study operationalises adversity using cumulative risk and latent class analysis (LCA) models to assess how adversity exposure and typologies may predict anxiety and depression in older adults. Data came from the Personality and Total Health (PATH) Through Life Project (N = 2551, age 60–66). Participants retrospectively reported their childhood experiences of domestic adversity on a 17-item scale. Mental health was measured using four validated questionnaires of depression and anxiety. Linear and generalised additive models (GAM) indicated a dose-response relationship, where a greater number of cumulative adversities were associated with poorer scores on all four mental health measures. LCA identified a four-class solution; with high adversity and high parental dysfunction being associated with poorer mental health outcomes while moderate parental dysfunction and low adversity groups scored at healthy levels. Women reported higher overall anxiety than men, but no notable interactions between ACEs and gender were observed. Patterns revealed by LCA were similar to patterns shown by the cumulative risk model. There is a large time gap from childhood to assessment, making our study susceptible to recall bias. Also, our findings were based on cross-sectional data, limiting causal inferences. Childhood adversity had independent and additive contributions to depression and anxiety in older adulthood, and both cumulative risk and person-centred approaches captured this relationship. •Cumulative childhood adversity is linked to anxiety and depression in older adults.•Latent ACE classes were differentially associated with anxiety and depression; but largely explained by cumulative risk.•Evidence suggests a long-term influence of childhood adversity on mental health that stretches into older adulthood.•Assessment of childhood adversity may be useful when screening for mental illness.