Risk factors associated with glomerular filtration rate in Mexican adults with type 2 diabetes mellitus

• Published in: Endocrinología, diabetes y nutrición. diabetes y nutrición., 2024-02, Vol.71 (2), p.44-52
• Main Authors: Mendoza López, Gloria, Morales Villar, Alva Belen, Tejada Bueno, Andrea Patricia, Lozada Hernández, Jessica, García Cortes, Luis Rey, Maldonado Hernández, Jorge
• Format: Article
• Language: English
• Subjects: Adult; Aged; Chronic kidney disease; Cross-Sectional Studies; Diabetes mellitus tipo 2; Diabetes Mellitus, Type 2 - complications; Enfermedad renal crónica; Female; Glomerular Filtration Rate; Glucose; Glycated Hemoglobin; Hiperfiltración; Humans; Hyperfiltration; Hypertension - complications; Hypertension - epidemiology; Male; Middle Aged; Obesidad; Obesity; Risk Factors; Tasa de filtración glomerular; Type 2 diabetes mellitus
• ISSN: 2530-0180; 2530-0180
• DOI: 10.1016/j.endien.2024.03.003

Type 2 diabetes mellitus (T2DM) is related to glomerular filtration rate (GFR) impairment, which is one of the main causes of chronic kidney disease. The objective of this study was to identify the risk factors related to GFR in Mexican adults with T2DM, using a validated multiple linear regression model (MLRM), with emphasis in body adiposity, glycemic control, duration of the diabetes and other relevant risk factors. A cross-sectional, analytical, and observational study was carried out in 252 adults with a previous diagnosis of T2DM. Body mass index (BMI) and waist circumference (WC) were determined and a fasting blood sample was collected for glucose, creatinine and HbA1c determinations. GFR was calculated with the Cockcroft–Gault equation adjusted for body surface area. Four MLRM were performed to determine the factors related to the GFR; it was evaluated whether these models complied with the statistical assumptions of the linear regression model. The average age of the participants was 60 ± 12 years, 62.3% of them were women. GFR correlated with BMI and WC; age and duration of the diabetes were associated inversely. Model 4 of the MLRM reported a coefficient of determination of 53.5% where the variables BMI (β = 1.31), male sex (β = −6.01), duration of T2DM (β = −0.57), arterial hypertension (β = −6.53) and age (β = −1.45) were simultaneously and significantly related to the GFR. Older age, male sex, longer duration of T2DM and the presence of arterial hypertension were associated with a decrease in the GFR; BMI and WC were directly associated. No effect of glucose and HbA1c on GFR was observed. La diabetes mellitus tipo 2 (DM2) se relaciona con afectaciones en la tasa de filtración glomerular (TFG) que es una de las principales causas de enfermedad renal crónica. El objetivo de este trabajo fue identificar los factores de riesgo relacionados con la TFG en adultos mexicanos con DM2, mediante un modelo de regresión lineal múltiple (RLM) validado, con énfasis en la adiposidad corporal, el control glucémico, el tiempo de evolución de la diabetes y otros factores de riesgo relevantes. Se realizó un estudio transversal, analítico y observacional en 252 adultos con diagnóstico previo de DM2. Se determinó el índice de masa corporal (IMC) y la circunferencia de cintura (CC) y se colectó una muestra sanguínea en ayuno para la determinación de glucosa, creatinina y HbA1c. La TFG se calculó con la ecuación Cockcroft-Gault (C-G) ajustada por superficie corporal