Aerobic physical capacity and health-related quality of life in children with sickle cell disease

Background Aerobic fitness is a predictor of cardiovascular health which correlates with health-related quality of life in the general population. The aim is to evaluate the aerobic capacity by cardiopulmonary exercise test (CPET) in children with sickle cell disease in comparison with healthy match...

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Published in:Pediatric research 2024-09, Vol.96 (4), p.1006-1012
Main Authors: Laurent-Lacroix, Corentin, Vincenti, Marie, Matecki, Stefan, Mahé, Perrine, Moulis, Lionel, De La Villeon, Gregoire, Guillaumont, Sophie, Requirand, Anne, Moreau, Johan, Lalande, Muriel, Picot, Marie-Christine, Amedro, Pascal, Gavotto, Arthur
Format: Article
Language:English
Subjects:
Anemia
Clinical Research Article
Lung diseases
Medicine
Medicine & Public Health
Mutation
Pediatric Surgery
Pediatrics
Physical fitness
Quality of life
Sickle cell disease
Standard scores
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Summary:Background Aerobic fitness is a predictor of cardiovascular health which correlates with health-related quality of life in the general population. The aim is to evaluate the aerobic capacity by cardiopulmonary exercise test (CPET) in children with sickle cell disease in comparison with healthy matched controls. Methods Controlled cross-sectional study. Results A total of 72 children (24 with sickle cell disease and 48 healthy controls), aged 6–17 years old were enrolled. Children with sickle cell disease had a poor aerobic capacity, with median VO 2max Z-score values significantly lower than matched controls (−3.55[−4.68; −2.02] vs. 0.25[−0.22; 0.66], P  
ISSN:0031-3998
1530-0447
1530-0447
DOI:10.1038/s41390-024-03143-1