Evaluation of Collagenase Activity from Crab Hepatopancreas in Different Model Systems

The effect of Kamchatka crab hepatopancreas containing three collagenolytic isoenzymes Collagenase KK and proteinases of Streptomyces lavendulae on metabolic activity and cell death were carried out on in vitro models. It was shown that changes in the protein structure under the influence of Collage...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2024-02, Vol.176 (4), p.457-460
Main Authors: Plekhova, N. G., Chernenko, I. N., Korolev, D. V., Kozlovskaya, E. P., Stepanyugina, A. K., Shevchenko, O. V., Dmitrenok, P. S., Shumatov, V. B.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biomedical and Life Sciences
Biomedicine
Brachyura - metabolism
Cell Biology
Cell culture
Cell death
Collagen
Collagenase
Collagenases - metabolism
Crustaceans
Cytotoxicity
Disaggregation
Drug dosages
Endopeptidases
Enzymes
Fibroblasts
Hepatopancreas
Hepatopancreas - metabolism
Internal Medicine
Isoenzymes
Laboratory Medicine
Melanoma
Metabolism
Pathology
Peptide Hydrolases
Protein structure
Proteins
Skin cancer
Toxicology
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Summary:The effect of Kamchatka crab hepatopancreas containing three collagenolytic isoenzymes Collagenase KK and proteinases of Streptomyces lavendulae on metabolic activity and cell death were carried out on in vitro models. It was shown that changes in the protein structure under the influence of Collagenase KK occurred earlier than under the effect of bacterial proteinases. At the same time, activity of Collagenase KK was significantly higher than that of bacterial proteinases ( p
ISSN:0007-4888
1573-8221
1573-8221
DOI:10.1007/s10517-024-06046-7