Prognostic significance of the preoperative C-reactive protein-albumin-lymphocyte (CALLY) index on outcomes after gastrectomy for gastric cancer

• Published in: Surgery today (Tokyo, Japan) Japan), 2024-08, Vol.54 (8), p.943-952
• Main Authors: Fukushima, Naoko, Masuda, Takahiro, Tsuboi, Kazuto, Takahashi, Keita, Yuda, Masami, Fujisaki, Muneharu, Ikegami, Toru, Yano, Fumiaki, Eto, Ken
• Format: Article
• Language: English
• Subjects: Aged; Biomarkers - blood; Blood Loss, Surgical - statistics & numerical data; C-Reactive Protein - analysis; Female; Gastrectomy - methods; Humans; Lymphocytes; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Staging; Original Article; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Preoperative Period; Prognosis; Serum Albumin - analysis; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Surgery; Surgical Oncology; Survival Rate; Treatment Outcome
• ISSN: 0941-1291; 1436-2813; 1436-2813
• DOI: 10.1007/s00595-024-02813-1

Purpose Systemic inflammatory response markers are reported to be prognostic for patients with cancer. The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index has been established as an immuno-nutritional scoring system. The aim of this study was to clarify the impact of the preoperative CALLY index on the outcome of patients undergoing gastrectomy for gastric cancer. Methods We analyzed the data of 826 patients who underwent gastrectomy for stage I, II, or III gastric cancer between 2010 and 2017. The CALLY index was defined as (albumin × lymphocyte)/(CRP × 10 4 ). Results The cut-off of the CALLY index was 2. The 147 patients with a preoperative CALLY index