The prediction of estimated cerebral perfusion pressure with trans-systolic time in preterm and term infants

It is important to monitor cerebral perfusion in infants because hypo- and hyperperfusion can contribute to neurological injury. This study aimed to clarify the relationship between trans-systolic time (TST) and critical closing pressure (CrCP) or estimated cerebral perfusion pressure (CPPe) in neon...

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Bibliographic Details
Published in:European journal of pediatrics 2024-06, Vol.183 (6), p.2587-2595
Main Authors: Zuiki, Masashi, Ohta, Mikito, Fujita, Naoe, Uda, Daisuke, Uesugi, Madoka, Yamano, Akio, Ichise, Eisuke, Morimoto, Hidechika, Hashiguchi, Kanae, Kinoshita, Daisuke, Hasegawa, Tatsuji, Iehara, Tomoko
Format: Article
Language:English
Subjects:
Arterial lines
Birth weight
Blood pressure
Carbon dioxide
Cerebrovascular Circulation - physiology
Doppler effect
Female
Flow velocity
Gestational Age
Hemodynamics
Humans
Hypertension
Hypotension
Infant, Newborn
Infant, Premature
Infants
Intensive care
Intensive care units
Intensive Care Units, Neonatal
Intracranial pressure
Male
Medicine
Medicine & Public Health
Middle Cerebral Artery - diagnostic imaging
Middle Cerebral Artery - physiopathology
Neonates
Pediatrics
Perfusion
Premature babies
Premature birth
Prospective Studies
Reference Values
Ultrasonic imaging
Ultrasonography, Doppler, Transcranial - methods
Ultrasound
Veins & arteries
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Summary:It is important to monitor cerebral perfusion in infants because hypo- and hyperperfusion can contribute to neurological injury. This study aimed to clarify the relationship between trans-systolic time (TST) and critical closing pressure (CrCP) or estimated cerebral perfusion pressure (CPPe) in neonates. Moreover, we aimed to determine the TST values in preterm and term infants with stable cerebral perfusion to clarify normative reference data. This multicentre prospective study included infants with arterial lines admitted to the neonatal intensive care units between December 2021 and August 2023. TST, CrCP, and CPPe were calculated using middle cerebral artery waveforms recorded using transcranial Doppler ultrasonography when clinicians collected arterial blood samples. Three hundred and sixty samples were obtained from 112 infants with a gestational age of 32 (interquartile range, 27–37) weeks and a birth weight of 1481 (956–2355) g. TST was positively correlated with CPPe (r = 0.60, p  
ISSN:1432-1076
0340-6199
1432-1076
DOI:10.1007/s00431-024-05511-9