Blood flow and emboli transport patterns during venoarterial extracorporeal membrane oxygenation: A computational fluid dynamics study

• Published in: Computers in biology and medicine 2024-04, Vol.172, p.108263-108263, Article 108263
• Main Authors: Khamooshi, Mehrdad, Wickramarachchi, Avishka, Byrne, Tim, Seman, Michael, Fletcher, David F., Burrell, Aidan, Gregory, Shaun D.
• Format: Article
• Language: English
• Subjects: Aorta; Aortic arch; Blood; Blood flow; Boundary conditions; Cannula; Cannulae; Cardiac output; Clinical medicine; Computational fluid dynamics; Computational neuroscience; Computed tomography; Coronary vessels; Deoxygenation; Emboli transport; Embolization; Extracorporeal membrane oxygenation; Femoral artery; Fluid dynamics; Harlequin syndrome; Heart; Hydrodynamics; Ischemia; Mathematical models; Mechanical circulatory support; Membranes; Mortality; Neurological complications; Oxygen; Oxygen content; Oxygenation; Particle tracking; Patients; Simulation; Stroke; Tomography; Veins & arteries; Velocity; Ventricle; Ventricles (cerebral); Watershed region
• ISSN: 0010-4825; 1879-0534
• DOI: 10.1016/j.compbiomed.2024.108263

Despite advances in Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO), a significant mortality rate persists due to complications. The non-physiological blood flow dynamics of VA-ECMO may lead to neurological complications and organ ischemia. Continuous retrograde high-flow oxygenated blood enters through a return cannula placed in the femoral artery which opposes the pulsatile deoxygenated blood ejected by the left ventricle (LV), which impacts upper body oxygenation and subsequent hyperoxemia. The complications underscore the critical need to comprehend the impact of VA-ECMO support level and return cannula size, as mortality remains a significant concern. The aim of this study is to predict and provide insights into the complications associated with VA-ECMO using computational fluid dynamics (CFD) simulations. These complications will be assessed by characterising blood flow and emboli transport patterns through a comprehensive analysis of the influence of VA-ECMO support levels and arterial return cannula sizes. Patient-specific 3D aortic and major branch models, derived from a male patient's CT scan during VA-ECMO undergoing respiratory dysfunction, were analyzed using CFD. The investigation employed species transport and discrete particle tracking models to study ECMO blood (oxygenated) mixing with LV blood (deoxygenated) and to trace emboli transport patterns from potential sources (circuit, LV, and aorta wall). Two cannula sizes (15 Fr and 19 Fr) were tested alongside varying ECMO pump flow rates (50%, 70%, and 90% of the total cardiac output). Cannula size did not significantly affect oxygen transport. At 90% VA-ECMO support, all arteries distal to the aortic arch achieved 100% oxygen saturation. As support level decreased, oxygen transport to the upper body also decreased to a minimum saturation of 73%. Emboli transport varied substantially between emboli origin and VAECMO support level, with the highest risk of cerebral emboli coming from the LV with a 15 Fr cannula at 90% support. Arterial return cannula sizing minimally impacted blood oxygen distribution; however, it did influence the distribution of emboli released from the circuit and aortic wall. Notably, it was the support level alone that significantly affected the mixing zone of VA-ECMO and cardiac blood, subsequently influencing the risk of embolization of the cardiogenic source and oxygenation levels across various arterial branches. [Display omitted] •Interaction between nati