Neutrophils, an emerging new therapeutic platform

Neutrophils possess unique characteristics that render them indispensable to health, and patients with irregular neutrophil counts or functions suffer from increased morbidity and mortality. As neutrophils are short-lived postmitotic cells, genetic aberrations cannot be corrected directly in neutrop...

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Bibliographic Details
Published in:Current opinion in biotechnology 2024-06, Vol.87, p.103106, Article 103106
Main Authors: López-Arredondo, Alejandra, Cruz-Cardenas, José A, Cázares-Preciado, Jorge A, Timmins, Nicholas E, Brunck, Marion EG
Format: Article
Language:English
Subjects:
Animals
Genetic Therapy - methods
Humans
Neoplasms - immunology
Neoplasms - therapy
Neutrophils - immunology
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Summary:Neutrophils possess unique characteristics that render them indispensable to health, and patients with irregular neutrophil counts or functions suffer from increased morbidity and mortality. As neutrophils are short-lived postmitotic cells, genetic aberrations cannot be corrected directly in neutrophils and must be targeted in their progenitors. Neutrophils are increasingly being contemplated for a range of therapeutic applications, including restoration or modulation of immune function and targeting of solid tumors. This review addresses the state-of-the-art in neutrophil transfusions and their possible applications for infectious disease prevention and treatment. It offers a landscape of the most recent gene therapy approaches to address neutrophil-related genetic diseases. We also discuss how ongoing research could broaden the applicability of neutrophil-based therapies to solid cancer treatments and beyond. [Display omitted] •Multiple challenges remain for the widespread use of granulocyte transfusions.•Ex vivo produced neutrophils offer a potential alternative to donor granulocytes.•Neutrophils and progenitors are being studied to treat a wide range of diseases.
ISSN:0958-1669
1879-0429
1879-0429
DOI:10.1016/j.copbio.2024.103106