Liposome-integrated hydrogel hybrids: Promising platforms for cancer therapy and tissue regeneration

• Published in: Journal of controlled release 2024-04, Vol.368, p.703-727
• Main Authors: Sanati, Mehdi, Amin Yavari, Saber
• Format: Article
• Language: English
• Subjects: Cancer; Hybrid platforms; Hydrogels; Liposomes; Tissue regeneration
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/j.jconrel.2024.03.008

Drug delivery platforms have gracefully emerged as an indispensable component of novel cancer chemotherapy, bestowing targeted drug distribution, elevating therapeutic effects, and reducing the burden of unwanted side effects. In this context, hybrid delivery systems artfully harnessing the virtues of liposomes and hydrogels bring remarkable benefits, especially for localized cancer therapy, including intensified stability, excellent amenability to hydrophobic and hydrophilic medications, controlled liberation behavior, and appropriate mucoadhesion to mucopenetration shift. Moreover, three-dimensional biocompatible liposome-integrated hydrogel networks have attracted unprecedented interest in tissue regeneration, given their tunable architecture and physicochemical properties, as well as enhanced mechanical support. This review elucidates and presents cutting-edge developments in recruiting liposome-integrated hydrogel systems for cancer treatment and tissue regeneration. [Display omitted] •Liposome-integrated hydrogel (Li-Gel) systems effectively mitigate the limitations inherent in individual platforms.•Li-Gel systems exhibit favorable biocompatibility, tunability, and physicochemical, structural, and mechanical properties.•Li-Gel systems could be therapeutically targeted or engineered as tailored drug delivery platforms.•Li-Gel systems bring notable benefits for localized cancer therapy and tissue regeneration.