Shear-Stress Profile along a Cell Focal Adhesion

Cell–substrate adhesion, such as for the porcine aortic endothelial cell shown in the figure, is investigated using a shear‐lag type mechanical model classically used in composite material science. The shape of the shear‐stress profile along the cell/substrate interface suggests a likely mechanism f...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2006-06, Vol.18 (12), p.1537-1540
Main Authors: Raz-Ben Aroush, D., Wagner, H. D.
Format: Article
Language:English
Subjects:
Biomaterials
Cells
Composites
Mechanical properties
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Summary:Cell–substrate adhesion, such as for the porcine aortic endothelial cell shown in the figure, is investigated using a shear‐lag type mechanical model classically used in composite material science. The shape of the shear‐stress profile along the cell/substrate interface suggests a likely mechanism for the biochemical feedback activity leading to a growth of the adhesion region. The role of various material and geometrical characteristics of the adhesion region is predicted.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200600372