Genotoxic effects of two industrial effluents and ethyl methane sulphonate in Clarias lazera

Clarias lazera (cat fish) kept in laboratory aquaria for 3 weeks and then exposed to 0.5, 1.0, 2.0, 4.0 or 8.0 mg ethyl methane sulphonate (EMS) per litre or 10, 20, 40 or 60 per cent brewery or textile-mill effluent for 14 d. Analysis of the frequency of numbers of micronucleated erythrocytes by li...

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Bibliographic Details
Published in:Food and chemical toxicology 1995-01, Vol.33 (6), p.501-505
Main Authors: Odeigah, P G C, Osanyipeju, A O
Format: Article
Language:English
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Summary:Clarias lazera (cat fish) kept in laboratory aquaria for 3 weeks and then exposed to 0.5, 1.0, 2.0, 4.0 or 8.0 mg ethyl methane sulphonate (EMS) per litre or 10, 20, 40 or 60 per cent brewery or textile-mill effluent for 14 d. Analysis of the frequency of numbers of micronucleated erythrocytes by linear regression and variance analysis showed a significant increase in micronucleus frequency following exposure to EMS or effluents with a positive dose-response over the whole range. The textile-mill effluent dose-response curve was significantly higher than that of the brewery effluent. The possibility of using the micronucleus test in fish for the screening of aquatic genotoxicants is discussed.
ISSN:0278-6915