Pollutants to pathogens: The role of heavy metals in modulating TGF-β signaling and lung cancer risk

• Published in: Pathology, research and practice research and practice, 2024-04, Vol.256, p.155260-155260, Article 155260
• Main Authors: Bhat, Asif Ahmad, Moglad, Ehssan, Bansal, Pooja, Kaur, Harpreet, Deorari, Mahamedha, Thapa, Riya, Almalki, Waleed Hassan, Kazmi, Imran, Alzarea, Sami I., Kukreti, Neelima, Ali, Haider
• Format: Article
• Language: English
• Subjects: And arsenic; Cadmium; Heavy metal; Lead; Lung cancer; Mercury; TGF-β signalling
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2024.155260

Lung cancer is a malignant tumor that develops in the lungs due to the uncontrolled growth of aberrant cells. Heavy metals, such as arsenic, cadmium, mercury, and lead, are metallic elements characterized by their high atomic weights and densities. Anthropogenic activities, such as industrial operations and pollution, have the potential to discharge heavy metals into the environment, hence presenting hazards to ecosystems and human well-being. The TGF-β signalling pathways have a crucial function in controlling several cellular processes, with the ability to both prevent and promote tumor growth. TGF-β regulates cellular responses by interacting in both canonical and non-canonical signalling pathways. Research employing both in vitro and in vivo models has shown that heavy metals may trigger TGF-β signalling via complex molecular pathways. Experiments conducted in a controlled laboratory environment show that heavy metals like cadmium and arsenic may directly bind to TGF-β receptors, leading to alterations in their structure that enable the receptor to be phosphorylated. Activation of this route sets in motion subsequent signalling cascades, most notably the canonical Smad pathway. The development of lung cancer has been linked to heavy metals, which are ubiquitous environmental pollutants. To grasp the underlying processes, it is necessary to comprehend their molecular effect on TGF-β pathways. With a particular emphasis on its consequences for lung cancer, this abstract delves into the complex connection between exposure to heavy metals and the stimulation of TGF-β signalling.