Studies of Mycotoxins in Medicinal Plants Conducted Worldwide over the Last Decade: A Systematic Review, Meta-Analysis, and Exposure Risk Assessment

• Published in: Phytomedicine (Stuttgart) 2024-06, Vol.128, p.155367-155367, Article 155367
• Main Authors: Wang, Yue, Su, Buda, Yan, Xingxu, Geng, Chenlei, Lian, Tingting, Li, Xiaomeng, Xu, Yanyan, Li, Yubo
• Format: Article
• Language: English
• Subjects: Aflatoxins - analysis; Enniatins; Food Contamination - analysis; Health risks; Humans; Mycotoxin contamination; Mycotoxins - analysis; Ochratoxins - analysis; Plants, Medicinal - chemistry; Risk Assessment; Risk characterization
• ISSN: 0944-7113; 1618-095X
• DOI: 10.1016/j.phymed.2024.155367

•A systematic review of mycotoxin contamination in medicinal plants was conducted.•The prevalence and concentration of mycotoxins were analyzed through meta-analysis.•The dietary exposure risk of mycotoxins was evaluated by the point assessment method.•Aflatoxins and ochratoxin A indicated risk in diverse traditional Chinese medicines.•Thus, the severity of mycotoxin contamination in medicinal plants should be reduced. Mycotoxins have been reported to be present in medicinal plants. With the growing usage of medicinal plants, contamination of mycotoxins has emerged as one of the biggest threats to global food hygiene and ecological environment, posing a severe threat to human health. This study aimed to determine the mycotoxin prevalence and levels in medicinal plants and conduct a risk assessment by conducting a systematic review and meta-analysis. A thorough search on Web of Science and PubMed was conducted for the last decade, resulting in 54 studies (meeting the inclusion criteria) with 2829 data items that were included in the meta-analysis. The combined prevalence of mycotoxins in medicinal plants was 1.7% (95% confidence interval, CI = 1.1% – 2.4%), with a mean mycotoxin concentration in medicinal plants of 3.551 µg/kg (95% CI = 3.461 – 3.641 µg/kg). Risk assessment results indicated that aflatoxins and ochratoxin A found in several medicinal plants posed a health risk to humans; additionally, emerging enniatins exhibited possible health risks. Therefore, the study underlines the need for establishing stringent control measures to reduce the severity of mycotoxin contamination in medicinal plants. [Display omitted]