Ketogenic Diet Alleviates Mechanical Allodynia in the Models of Inflammatory and Neuropathic Pain in Male Mice

• Published in: Biological & pharmaceutical bulletin 2024/03/15, Vol.47(3), pp.629-634
• Main Authors: Eto, Kei, Ogata, Masanori, Toyooka, Yoshitaka, Hayashi, Toru, Ishibashi, Hitoshi
• Format: Article
• Language: English
• Subjects: Animal models; Chronic pain; Edema; Formaldehyde; High carbohydrate diet; High fat diet; Inflammation; Ketogenesis; ketogenic diet; Low carbohydrate diet; Low fat diet; Low protein diet; nerve injury; Neuralgia; Nutrient deficiency; Pain perception; Peripheral nerves
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.b23-00732

Inflammation is involved in the induction of chronic inflammatory and neuropathic pain. Moreover, the ketogenic diet, a high-fat, low-carbohydrate, and adequate protein diet, has an anti-inflammatory effect. Thus, we hypothesized that a ketogenic diet has a therapeutic effect on both types of chronic pain. In the present study, we investigated the effect of a ketogenic diet on mechanical allodynia, a chronic pain symptom, in formalin-induced chronic inflammatory pain and nerve injury-induced neuropathic pain models using adult male mice. Formalin injection into the hind paw induced mechanical allodynia in both the injected and intact hind paws, and the ketogenic diet alleviated mechanical allodynia in both hind paws. In addition, the ketogenic diet prevented formalin-induced edema. Furthermore, the diet alleviated mechanical allodynia induced by peripheral nerve injury. Thus, these findings indicate that a ketogenic diet has a therapeutic effect on chronic pain induced by inflammation and nerve injury.