Prevalence and predictors of female sexual dysfunction among sexually active women in the diabetes prevention program outcomes study

• Published in: Neurourology and urodynamics 2024-04, Vol.43 (4), p.977-990
• Main Authors: Gupta, Priyanka, Doherty, Lindsay, Temprosa, Marinella, Pop‐Busui, Rodica, Gadde, Kishore M., Singh, Prachi, Owora, Arthur H., Wessells, Hunter, Sarma, Aruna V.
• Format: Article
• Language: English
• Subjects: Autonomic nervous system; Body mass index; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetic neuropathy; EKG; female sexual dysfunction; Females; Heart diseases; Heart rate; Hysterectomy; Peripheral neuropathy; Prevention programs; Sexual disorders; sexual health; Urinary incontinence
• ISSN: 0733-2467; 1520-6777
• DOI: 10.1002/nau.25436

Objective To determine the burden and identify correlates of female sexual dysfunction (FSD) among women with prediabetes (PreD) and type 2 diabetes (T2D) enrolled in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS). Methods The DPPOS visit included the Female Sexual Function Index (FSFI) to determine sexual function. Of 1464 participants, 1320 (90%) completed the (FSFI) and 426 were sexually active. A backward selection multivariable logistic regression model estimated the odds of FSD for sociodemographic, clinical, and diabetes‐related covariates. Results One hundred and eighty‐five (43%) had a score of ≤26.55 and met the criteria for FSD. After adjustment for DPP treatment and age, urinary incontinence (UI) (odds ratio [OR] = 1.91, 95% confidence interval [CI] = 1.15–3.17) and hysterectomy (OR = 1.89, 95% CI = 1.01–3.53) were associated with increased odds of FSD. Increased body mass index was protective for FSD (OR = 0.93 per kg/m2, 95% CI = 0.89–0.96). Michigan Neuropathy Screening Instrument‐based peripheral neuropathy (mean±SD scores 1.1±1.3 vs. 0.9±1.1, p