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Quantitative evaluation of morphological and functional changes in meibomian glands and lipid layer thickness in patients with and without keratoconus
Purpose To quantitatively evaluate the morphological parameters of meibomian glands (MGs) and lipid layer thickness (LLT) in patients with keratoconus (KC). Methods In this prospective, cross-sectional study, 164 eyes of 164 keratoconus patients and 64 eyes of 64 age-matched control subjects were in...
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| Published in: | Graefe's archive for clinical and experimental ophthalmology 2024-08, Vol.262 (8), p.2551-2560 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
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| creator | Hou, Xiangtao Liu, Chang Luo, Yiqi Yu, Na Chen, Pei Zhuang, Jing Yu, Keming |
| description | Purpose
To quantitatively evaluate the morphological parameters of meibomian glands (MGs) and lipid layer thickness (LLT) in patients with keratoconus (KC).
Methods
In this prospective, cross-sectional study, 164 eyes of 164 keratoconus patients and 64 eyes of 64 age-matched control subjects were included. An advanced automatic MG analyzer was used to quantitatively measure the morphological and functional parameters of MGs. Morphological and functional parameters of MGs, LLT, and other ocular surface parameters were compared between the control and KC groups.
Results
The mean meibomian gland diameter, length, square, and gland area ratio (GA) were all significantly decreased in the KC group (all
P
0.05). There was no significant difference in the number of total and incomplete blinking among patients with different stages of keratoconus (all
P
> 0.05). The gland diameter, square, and TI were all negatively associated with KC severity (all
P
0.05). Moreover, the LLTs were positively correlated with the gland diameter, square, GA, and TI and negatively correlated with anterior corneal curvature or KC severity (all
P
|
| doi_str_mv | 10.1007/s00417-024-06443-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2972702331</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3082702932</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-88321021637761ec5767a9109f1c7140893f87dbbc89abf83e8d792bc25000983</originalsourceid><addsrcrecordid>eNp9kc1O3DAUhS1UVKbQF2BRWeqGTah_kthZVqi0lZBQJZDYWY7HmTEkduofKl6kz8vNDG2lLtjY17qfj33PQeiUknNKiPiUCKmpqAirK9LWNa_kAVrRmjeVIOzuDVoRwWglObs7Qu9SuifA84a-RUdcNoTxhqzQ7x9F--yyzu7RYvuoxwJl8DgMeApx3oYxbJzRI9Z-jYfizdKFo9lqv7EJO48n6_owOe3xZgQq7dDRzQ5W_WQjzltnHrxNO3oGfetzwr9c3u7QpQgl4wcbdQ4m-JJO0OGgx2Tfv-zH6Pbyy83Ft-rq-uv3i89XleGszZWE4ShhtOVCtNSaRrRCd5R0AzWC1kR2fJBi3fdGdrofJLdyLTrWG9aAGZ3kx-hsrzvH8LPYlNXkkrEjzGFDSYp1goGZnFNAP_6H3ocSwYqkOJEL1XEGFNtTJoaUoh3UHN2k45OiRC2pqX1qClJTu9TU8osPL9Kln-z675U_MQHA90CCFtge_739iuwzF4Gkig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3082702932</pqid></control><display><type>article</type><title>Quantitative evaluation of morphological and functional changes in meibomian glands and lipid layer thickness in patients with and without keratoconus</title><source>Springer Nature</source><creator>Hou, Xiangtao ; Liu, Chang ; Luo, Yiqi ; Yu, Na ; Chen, Pei ; Zhuang, Jing ; Yu, Keming</creator><creatorcontrib>Hou, Xiangtao ; Liu, Chang ; Luo, Yiqi ; Yu, Na ; Chen, Pei ; Zhuang, Jing ; Yu, Keming</creatorcontrib><description>Purpose
To quantitatively evaluate the morphological parameters of meibomian glands (MGs) and lipid layer thickness (LLT) in patients with keratoconus (KC).
Methods
In this prospective, cross-sectional study, 164 eyes of 164 keratoconus patients and 64 eyes of 64 age-matched control subjects were included. An advanced automatic MG analyzer was used to quantitatively measure the morphological and functional parameters of MGs. Morphological and functional parameters of MGs, LLT, and other ocular surface parameters were compared between the control and KC groups.
Results
The mean meibomian gland diameter, length, square, and gland area ratio (GA) were all significantly decreased in the KC group (all
P
< 0.05), while no significant difference was observed in the gland tortuosity index (TI) and gland signal index (SI) between the KC and control groups (all
P
> 0.05). There was no significant difference in the number of total and incomplete blinking among patients with different stages of keratoconus (all
P
> 0.05). The gland diameter, square, and TI were all negatively associated with KC severity (all
P
< 0.05), while no significant difference was observed among all stages of KC in gland length, GA, and SI (all
P
> 0.05). Moreover, the LLTs were positively correlated with the gland diameter, square, GA, and TI and negatively correlated with anterior corneal curvature or KC severity (all
P
< 0.05).
Conclusions
Atrophic morphological changes in the meibomian glands were closely correlated with the severity of keratoconus. Gland diameter may be a sensitive functional morphology metric of meibomian glands in patients with keratoconus.</description><identifier>ISSN: 0721-832X</identifier><identifier>ISSN: 1435-702X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-024-06443-8</identifier><identifier>PMID: 38502350</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cornea ; Functional morphology ; Glands ; Keratoconus ; Medicine ; Medicine & Public Health ; Morphology ; Ophthalmology</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2024-08, Vol.262 (8), p.2551-2560</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-88321021637761ec5767a9109f1c7140893f87dbbc89abf83e8d792bc25000983</cites><orcidid>0000-0003-1943-5736</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38502350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Xiangtao</creatorcontrib><creatorcontrib>Liu, Chang</creatorcontrib><creatorcontrib>Luo, Yiqi</creatorcontrib><creatorcontrib>Yu, Na</creatorcontrib><creatorcontrib>Chen, Pei</creatorcontrib><creatorcontrib>Zhuang, Jing</creatorcontrib><creatorcontrib>Yu, Keming</creatorcontrib><title>Quantitative evaluation of morphological and functional changes in meibomian glands and lipid layer thickness in patients with and without keratoconus</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To quantitatively evaluate the morphological parameters of meibomian glands (MGs) and lipid layer thickness (LLT) in patients with keratoconus (KC).
Methods
In this prospective, cross-sectional study, 164 eyes of 164 keratoconus patients and 64 eyes of 64 age-matched control subjects were included. An advanced automatic MG analyzer was used to quantitatively measure the morphological and functional parameters of MGs. Morphological and functional parameters of MGs, LLT, and other ocular surface parameters were compared between the control and KC groups.
Results
The mean meibomian gland diameter, length, square, and gland area ratio (GA) were all significantly decreased in the KC group (all
P
< 0.05), while no significant difference was observed in the gland tortuosity index (TI) and gland signal index (SI) between the KC and control groups (all
P
> 0.05). There was no significant difference in the number of total and incomplete blinking among patients with different stages of keratoconus (all
P
> 0.05). The gland diameter, square, and TI were all negatively associated with KC severity (all
P
< 0.05), while no significant difference was observed among all stages of KC in gland length, GA, and SI (all
P
> 0.05). Moreover, the LLTs were positively correlated with the gland diameter, square, GA, and TI and negatively correlated with anterior corneal curvature or KC severity (all
P
< 0.05).
Conclusions
Atrophic morphological changes in the meibomian glands were closely correlated with the severity of keratoconus. Gland diameter may be a sensitive functional morphology metric of meibomian glands in patients with keratoconus.</description><subject>Cornea</subject><subject>Functional morphology</subject><subject>Glands</subject><subject>Keratoconus</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morphology</subject><subject>Ophthalmology</subject><issn>0721-832X</issn><issn>1435-702X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc1O3DAUhS1UVKbQF2BRWeqGTah_kthZVqi0lZBQJZDYWY7HmTEkduofKl6kz8vNDG2lLtjY17qfj33PQeiUknNKiPiUCKmpqAirK9LWNa_kAVrRmjeVIOzuDVoRwWglObs7Qu9SuifA84a-RUdcNoTxhqzQ7x9F--yyzu7RYvuoxwJl8DgMeApx3oYxbJzRI9Z-jYfizdKFo9lqv7EJO48n6_owOe3xZgQq7dDRzQ5W_WQjzltnHrxNO3oGfetzwr9c3u7QpQgl4wcbdQ4m-JJO0OGgx2Tfv-zH6Pbyy83Ft-rq-uv3i89XleGszZWE4ShhtOVCtNSaRrRCd5R0AzWC1kR2fJBi3fdGdrofJLdyLTrWG9aAGZ3kx-hsrzvH8LPYlNXkkrEjzGFDSYp1goGZnFNAP_6H3ocSwYqkOJEL1XEGFNtTJoaUoh3UHN2k45OiRC2pqX1qClJTu9TU8osPL9Kln-z675U_MQHA90CCFtge_739iuwzF4Gkig</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Hou, Xiangtao</creator><creator>Liu, Chang</creator><creator>Luo, Yiqi</creator><creator>Yu, Na</creator><creator>Chen, Pei</creator><creator>Zhuang, Jing</creator><creator>Yu, Keming</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1943-5736</orcidid></search><sort><creationdate>20240801</creationdate><title>Quantitative evaluation of morphological and functional changes in meibomian glands and lipid layer thickness in patients with and without keratoconus</title><author>Hou, Xiangtao ; Liu, Chang ; Luo, Yiqi ; Yu, Na ; Chen, Pei ; Zhuang, Jing ; Yu, Keming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-88321021637761ec5767a9109f1c7140893f87dbbc89abf83e8d792bc25000983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cornea</topic><topic>Functional morphology</topic><topic>Glands</topic><topic>Keratoconus</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morphology</topic><topic>Ophthalmology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, Xiangtao</creatorcontrib><creatorcontrib>Liu, Chang</creatorcontrib><creatorcontrib>Luo, Yiqi</creatorcontrib><creatorcontrib>Yu, Na</creatorcontrib><creatorcontrib>Chen, Pei</creatorcontrib><creatorcontrib>Zhuang, Jing</creatorcontrib><creatorcontrib>Yu, Keming</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, Xiangtao</au><au>Liu, Chang</au><au>Luo, Yiqi</au><au>Yu, Na</au><au>Chen, Pei</au><au>Zhuang, Jing</au><au>Yu, Keming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative evaluation of morphological and functional changes in meibomian glands and lipid layer thickness in patients with and without keratoconus</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>262</volume><issue>8</issue><spage>2551</spage><epage>2560</epage><pages>2551-2560</pages><issn>0721-832X</issn><issn>1435-702X</issn><eissn>1435-702X</eissn><abstract>Purpose
To quantitatively evaluate the morphological parameters of meibomian glands (MGs) and lipid layer thickness (LLT) in patients with keratoconus (KC).
Methods
In this prospective, cross-sectional study, 164 eyes of 164 keratoconus patients and 64 eyes of 64 age-matched control subjects were included. An advanced automatic MG analyzer was used to quantitatively measure the morphological and functional parameters of MGs. Morphological and functional parameters of MGs, LLT, and other ocular surface parameters were compared between the control and KC groups.
Results
The mean meibomian gland diameter, length, square, and gland area ratio (GA) were all significantly decreased in the KC group (all
P
< 0.05), while no significant difference was observed in the gland tortuosity index (TI) and gland signal index (SI) between the KC and control groups (all
P
> 0.05). There was no significant difference in the number of total and incomplete blinking among patients with different stages of keratoconus (all
P
> 0.05). The gland diameter, square, and TI were all negatively associated with KC severity (all
P
< 0.05), while no significant difference was observed among all stages of KC in gland length, GA, and SI (all
P
> 0.05). Moreover, the LLTs were positively correlated with the gland diameter, square, GA, and TI and negatively correlated with anterior corneal curvature or KC severity (all
P
< 0.05).
Conclusions
Atrophic morphological changes in the meibomian glands were closely correlated with the severity of keratoconus. Gland diameter may be a sensitive functional morphology metric of meibomian glands in patients with keratoconus.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38502350</pmid><doi>10.1007/s00417-024-06443-8</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1943-5736</orcidid></addata></record> |
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| issn | 0721-832X 1435-702X 1435-702X |
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| source | Springer Nature |
| subjects | Cornea Functional morphology Glands Keratoconus Medicine Medicine & Public Health Morphology Ophthalmology |
| title | Quantitative evaluation of morphological and functional changes in meibomian glands and lipid layer thickness in patients with and without keratoconus |
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