Comparison of miRNA profiles in the immune response of pediatric acute appendicitis and pediatric enterobiasis patients caused by Enterobius vermicularis

The aim of this study was to determine and compare the miRNA profile in the immune response with the parasite in pediatric patients with acute appendicitis caused by Enterobius vermicularis and in pediatric patients with enterobiasis. A total of 30 tissue samples, which were operated with the diagno...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2024-07, Vol.118 (7), p.458-464
Main Authors: Öztürk, Ayşe Betül, Eroglu, Fadime
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Animals
Appendicitis - immunology
Appendicitis - parasitology
B-Lymphocytes - immunology
Child
Child, Preschool
Enterobiasis
Enterobius
Female
Humans
Male
MicroRNAs
T-Lymphocytes - immunology
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Summary:The aim of this study was to determine and compare the miRNA profile in the immune response with the parasite in pediatric patients with acute appendicitis caused by Enterobius vermicularis and in pediatric patients with enterobiasis. A total of 30 tissue samples, which were operated with the diagnosis of pediatric acute appendicitis in the last 10 y and Enterobius vermicularis was detected by histopathological findings, were analyzed. In addition, blood samples were taken from 30 pediatric patients diagnosed with enterobiasis for this study. The miRNAs that activate T and B cells were evaluated by a quantitative real-time PCR, statistically calculated within ΔΔCt values, and fold changes were evaluated by Welch's T test, in which p
ISSN:0035-9203
1878-3503
1878-3503
DOI:10.1093/trstmh/trae011