Application of hydrogel microneedles in the oral cavity

Microneedles are a transdermal drug delivery system in which the needle punctures the epithelium to deliver the drug directly to deep tissues, thus avoiding the influence of the first‐pass effect of the gastrointestinal tract and minimizing the likelihood of pain induction. Hydrogel microneedles are...

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Bibliographic Details
Published in:Biopolymers 2024-05, Vol.115 (3), p.e23573-n/a
Main Authors: He, Yiyao, He, Dawei, Fan, Lin, Ren, Song, Wang, Lin, Sun, Jiang
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Controllability
controlled release
Drug delivery
Drug delivery systems
Drug Delivery Systems - instrumentation
Drug Delivery Systems - methods
Environmental control
Epithelium
Gastrointestinal system
Gastrointestinal tract
Humans
hydrogel
Hydrogels
Hydrogels - chemistry
Mechanical properties
Microinjections - instrumentation
Microinjections - methods
microneedle
Mouth
Needles
Oral cavity
oral disease
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Summary:Microneedles are a transdermal drug delivery system in which the needle punctures the epithelium to deliver the drug directly to deep tissues, thus avoiding the influence of the first‐pass effect of the gastrointestinal tract and minimizing the likelihood of pain induction. Hydrogel microneedles are microneedles prepared from hydrogels that have good biocompatibility, controllable mechanical properties, and controllable drug release and can be modified to achieve environmental control of drug release in vivo. The large epithelial tissue in the oral cavity is an ideal site for drug delivery via microneedles. Hydrogel microneedles can overcome mucosal hindrances to delivering drugs to deep tissues; this prevents humidity and a highly dynamic environment in the oral cavity from influencing the efficacy of the drugs and enables them to obtain better therapeutic effects. This article analyzes the materials and advantages of common hydrogel microneedles and reviews the application of hydrogel microneedles in the oral cavity.
ISSN:0006-3525
1097-0282
1097-0282
DOI:10.1002/bip.23573