Identification of CAF-related lncRNAs at the pan-cancer level represents a potential carcinogenic risk

Cancer-associated fibroblasts (CAFs) are increasingly recognized as playing a crucial role in regulating cancer progression and metastasis. These cells can be activated by long non-coding RNAs (lncRNAs), promoting the malignant biological processes of tumor cells. Therefore, it is essential to under...

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Bibliographic Details
Published in:Human molecular genetics 2024-06, Vol.33 (12), p.1064
Main Authors: Wang, Mingwei, Jiang, Minghui, Xie, Aimin, Zhang, Nan, Xu, Yan
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cancer-Associated Fibroblasts - metabolism
Cancer-Associated Fibroblasts - pathology
Carcinogenesis - genetics
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Neoplasms - genetics
Neoplasms - pathology
RNA, Long Noncoding - genetics
Tumor Microenvironment - genetics
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Summary:Cancer-associated fibroblasts (CAFs) are increasingly recognized as playing a crucial role in regulating cancer progression and metastasis. These cells can be activated by long non-coding RNAs (lncRNAs), promoting the malignant biological processes of tumor cells. Therefore, it is essential to understand the regulatory relationship between CAFs and lncRNAs in cancers. Here, we identified CAF-related lncRNAs at the pan-cancer level to systematically predict their potential regulatory functions. The identified lncRNAs were also validated using various external data at both tissue and cellular levels. This study has revealed that these CAF-related lncRNAs exhibit expression perturbations in cancers and are highly correlated with the infiltration of stromal cells, particularly fibroblasts and endothelial cells. By prioritizing a list of CAF-related lncRNAs, we can further distinguish patient subtypes that show survival and molecular differences. In addition, we have developed a web server, CAFLnc (https://46906u5t63.zicp.fun/CAFLnc/), to visualize our results. In conclusion, CAF-related lncRNAs hold great potential as a valuable resource for comprehending lncRNA functions and advancing the identification of biomarkers for cancer progression and therapeutic targets in cancer treatment.
ISSN:0964-6906
1460-2083
1460-2083
DOI:10.1093/hmg/ddae042