Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease

• Published in: Clinical and experimental nephrology 2024-08, Vol.28 (8), p.784-792
• Main Authors: Kishi, Seiji, Nakashima, Takaya, Goto, Tadahiro, Nagasu, Hajime, Brooks, Craig R., Okada, Hirokazu, Tamura, Kouichi, Nakano, Toshiaki, Narita, Ichiei, Maruyama, Shoichi, Yano, Yuichiro, Yokoo, Takashi, Wada, Takashi, Wada, Jun, Nangaku, Masaomi, Kashihara, Naoki
• Format: Article
• Language: English
• Subjects: Aged; Disease Progression; Epidermal growth factor receptors; Female; Glomerular Filtration Rate; Humans; Japan - epidemiology; Kidney - physiopathology; Kidney diseases; Magnesium; Magnesium - blood; Magnesium Deficiency - blood; Magnesium Deficiency - complications; Male; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Original Article; Prognosis; Prospective Studies; Renal function; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - diagnosis; Renal Insufficiency, Chronic - physiopathology; Urology
• ISSN: 1342-1751; 1437-7799; 1437-7799
• DOI: 10.1007/s10157-024-02486-7

Background Magnesium deficiency is associated with various health conditions, but its impact on the progression of chronic kidney disease (CKD) remains unclear. This study aimed to investigate the association between serum magnesium levels and prognosis of renal function in CKD patients. Methods This is an analysis of the Japan Chronic Kidney Disease Database Ex　(J-CKD-DB-Ex), which is a multicenter prospective cohort including CKD patients enrolled from January 1, 2014 to December 31, 2020. We included adult outpatients with CKD stage G3 and G4 at the time of initial magnesium measurement. Patients were classified by magnesium levels as low (2.6 mg/dl). The primary outcomes were the composite of an eGFR