Serum Uric Acid Levels among Chinese Children: Reference Values and Association With Overweight/Obesity

This study aimed to investigate the reference values for serum uric acid (SUA) levels and their association with overweight/obese in children. We conducted a retrospective analysis of 8522 participants, including 6227 normal weight children, aged 2 to 18 years in China. Among normal children, SUA le...

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Bibliographic Details
Published in:Clinical pediatrics 2024-12, Vol.63 (12), p.1684-1690
Main Authors: Ye, Wenjing, Zhou, Xinhe, Xu, Yanping, Zheng, Chao, Liu, Peining
Format: Article
Language:English
Subjects:
Adolescent
Body Mass Index
Body weight
Child
Child, Preschool
Children
China - epidemiology
East Asian People
Female
Humans
Male
Obesity
Overweight
Overweight - blood
Overweight - epidemiology
Pediatric Obesity - blood
Pediatric Obesity - epidemiology
Reference Values
Retrospective Studies
Sex differences
Uric acid
Uric Acid - blood
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Summary:This study aimed to investigate the reference values for serum uric acid (SUA) levels and their association with overweight/obese in children. We conducted a retrospective analysis of 8522 participants, including 6227 normal weight children, aged 2 to 18 years in China. Among normal children, SUA levels increased with age, showing significant sex differences in children over 10 years. Age-specific and sex-specific 95% reference intervals for SUA levels were established. Furthermore, we observed that the percentage of overweight/obesity significantly increased as SUA quartiles rose. Elevated SUA levels were associated with a high odds ratio (OR) for overweight/obesity (OR = 4.45, 95% confidence interval = 3.33, 5.93). We propose that the 97.5th percentile is a suitable value for defining elevated SUA levels, and there is a positive correlation between SUA levels and the presence of overweight or obesity.
ISSN:0009-9228
1938-2707
1938-2707
DOI:10.1177/00099228241238510