Pathogenic Potential of Eomesodermin‐Expressing T‐Helper Cells in Neurodegenerative Diseases

Eomesodermin‐expressing (Eomes+) T‐helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes+ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme...

Full description

Saved in:
Bibliographic Details
Published in:Annals of neurology 2024-06, Vol.95 (6), p.1093-1098
Main Authors: Kanazawa, Tomomi, Sato, Wakiro, Raveney, Ben J.E., Takewaki, Daiki, Kimura, Atsuko, Yamaguchi, Hiromi, Yokoi, Yuma, Saika, Reiko, Takahashi, Yuji, Fujita, Tsuneo, Saiki, Shinji, Tamaoka, Akira, Oki, Shinji, Yamamura, Takashi
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - immunology
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - immunology
Cognitive ability
Cytotoxicity
Female
Granzyme B
Granzymes - metabolism
Helper cells
Humans
Lymphocytes T
Male
Middle Aged
Multiple sclerosis
Neurodegenerative diseases
Neurodegenerative Diseases - immunology
Peripheral blood
T-Box Domain Proteins - metabolism
T-Lymphocytes, Helper-Inducer - immunology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Eomesodermin‐expressing (Eomes+) T‐helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes+ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes+ Th cells was observed in the initial (acutely progressive) stage of amyotrophic lateral sclerosis, and a positive correlation between Eomes+ Th cell frequency and cognitive decline was observed in Alzheimer's disease patients. Therefore, Eomes+ Th cells may be involved in the pathology of amyotrophic lateral sclerosis and Alzheimer's disease. ANN NEUROL 2024;95:1093–1098
ISSN:0364-5134
1531-8249
1531-8249
DOI:10.1002/ana.26920