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Pathogenic Potential of Eomesodermin‐Expressing T‐Helper Cells in Neurodegenerative Diseases
Eomesodermin‐expressing (Eomes+) T‐helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes+ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme...
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| Published in: | Annals of neurology 2024-06, Vol.95 (6), p.1093-1098 |
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| Main Authors: | , , , , , , , , , , , , , |
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| container_end_page | 1098 |
| container_issue | 6 |
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| container_title | Annals of neurology |
| container_volume | 95 |
| creator | Kanazawa, Tomomi Sato, Wakiro Raveney, Ben J.E. Takewaki, Daiki Kimura, Atsuko Yamaguchi, Hiromi Yokoi, Yuma Saika, Reiko Takahashi, Yuji Fujita, Tsuneo Saiki, Shinji Tamaoka, Akira Oki, Shinji Yamamura, Takashi |
| description | Eomesodermin‐expressing (Eomes+) T‐helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes+ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes+ Th cells was observed in the initial (acutely progressive) stage of amyotrophic lateral sclerosis, and a positive correlation between Eomes+ Th cell frequency and cognitive decline was observed in Alzheimer's disease patients. Therefore, Eomes+ Th cells may be involved in the pathology of amyotrophic lateral sclerosis and Alzheimer's disease. ANN NEUROL 2024;95:1093–1098 |
| doi_str_mv | 10.1002/ana.26920 |
| format | article |
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We found that Eomes+ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes+ Th cells was observed in the initial (acutely progressive) stage of amyotrophic lateral sclerosis, and a positive correlation between Eomes+ Th cell frequency and cognitive decline was observed in Alzheimer's disease patients. Therefore, Eomes+ Th cells may be involved in the pathology of amyotrophic lateral sclerosis and Alzheimer's disease. 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Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3480-e0aba78cfe9310e468a63db91584d71c2a5bd7f3a13f2a2fa17f366da503b9f83</cites><orcidid>0009-0008-3772-0665 ; 0000-0003-2641-5733 ; 0000-0002-9732-8488</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38516846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanazawa, Tomomi</creatorcontrib><creatorcontrib>Sato, Wakiro</creatorcontrib><creatorcontrib>Raveney, Ben J.E.</creatorcontrib><creatorcontrib>Takewaki, Daiki</creatorcontrib><creatorcontrib>Kimura, Atsuko</creatorcontrib><creatorcontrib>Yamaguchi, Hiromi</creatorcontrib><creatorcontrib>Yokoi, Yuma</creatorcontrib><creatorcontrib>Saika, Reiko</creatorcontrib><creatorcontrib>Takahashi, Yuji</creatorcontrib><creatorcontrib>Fujita, Tsuneo</creatorcontrib><creatorcontrib>Saiki, Shinji</creatorcontrib><creatorcontrib>Tamaoka, Akira</creatorcontrib><creatorcontrib>Oki, Shinji</creatorcontrib><creatorcontrib>Yamamura, Takashi</creatorcontrib><title>Pathogenic Potential of Eomesodermin‐Expressing T‐Helper Cells in Neurodegenerative Diseases</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Eomesodermin‐expressing (Eomes+) T‐helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. 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| subjects | Aged Aged, 80 and over Alzheimer Disease - immunology Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - immunology Cognitive ability Cytotoxicity Female Granzyme B Granzymes - metabolism Helper cells Humans Lymphocytes T Male Middle Aged Multiple sclerosis Neurodegenerative diseases Neurodegenerative Diseases - immunology Peripheral blood T-Box Domain Proteins - metabolism T-Lymphocytes, Helper-Inducer - immunology |
| title | Pathogenic Potential of Eomesodermin‐Expressing T‐Helper Cells in Neurodegenerative Diseases |
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