Pancreatic cancer detection with dual-energy CT: diagnostic performance of 40 keV and 70 keV virtual monoenergetic images

Purpose To compare the diagnostic performance of 40 keV and 70 keV virtual monoenergetic images (VMIs) generated from dual-energy CT in the detection of pancreatic cancer. Methods This retrospective study included patients who underwent pancreatic protocol dual-energy CT from January 2019 to August...

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Bibliographic Details
Published in:Radiologia medica 2024-05, Vol.129 (5), p.677-686
Main Authors: Noda, Yoshifumi, Ando, Tomohiro, Kaga, Tetsuro, Yamda, Nao, Seko, Takuya, Ishihara, Takuma, Kawai, Nobuyuki, Miyoshi, Toshiharu, Ito, Akio, Naruse, Takuya, Hyodo, Fuminori, Kato, Hiroki, Kambadakone, Avinash R., Matsuo, Masayuki
Format: Article
Language:English
Subjects:
Abdominal Radiology
Aged
Cancer
Computed tomography
Diagnostic Radiology
Diagnostic systems
Female
Humans
Imaging
Interventional Radiology
Male
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Pancreatic cancer
Pancreatic Neoplasms - diagnostic imaging
Predictive Value of Tests
Radiography, Dual-Energy Scanned Projection - methods
Radiology
Retrospective Studies
Sensitivity
Sensitivity and Specificity
Tomography, X-Ray Computed - methods
Ultrasound
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Summary:Purpose To compare the diagnostic performance of 40 keV and 70 keV virtual monoenergetic images (VMIs) generated from dual-energy CT in the detection of pancreatic cancer. Methods This retrospective study included patients who underwent pancreatic protocol dual-energy CT from January 2019 to August 2022. Four radiologists (1–11 years of experience), who were blinded to the final diagnosis, independently and randomly interpreted 40 keV and 70 keV VMIs and graded the presence or absence of pancreatic cancer. For each image set (40 keV and 70 keV VMIs), the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. The diagnostic performance of each image set was compared using generalized estimating equations. Results Overall, 137 patients (median age, 71 years; interquartile range, 63–78 years; 77 men) were included. Among them, 62 patients (45%) had pathologically proven pancreatic cancer. The 40 keV VMIs had higher specificity (75% vs. 67%; P  
ISSN:1826-6983
0033-8362
1826-6983
DOI:10.1007/s11547-024-01806-x