Evaluation of changes in exhausted T lymphocytes and miRNAs expression in the different trimesters of pregnancy in pregnant women

Background Throughout the three trimesters of a typical pregnancy, we looked at changes in the expression of miRNAs and exhausted T lymphocytes for this study. Methods and results Fifty healthy subjects were included in this study. The frequency of exhausted T lymphocytes was measured in isolated PB...

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Published in:Molecular biology reports 2024-12, Vol.51 (1), p.442-442, Article 442
Main Authors: Shekarchi, Ali Akbar, Hosseini, Leila, Kamrani, Amin, Alipourfard, Iraj, Soltani-Zangbar, Mohammad Sadegh, Akbari, Morteza, Roshangar, Leila, Aghebati-Maleki, Leili, Chakari-Khiavi, Forough, Chakari-Khiavi, Aref, Motlagh Asghari, Kimia, Danaii, Shahla, Pourlak, Tannaz, Ahmadian Heris, Javad, Yousefi, Mehdi
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
CD4 antigen
CD8 antigen
Flow cytometry
Gene expression
Histology
Life Sciences
Lymphocytes
Lymphocytes T
Morphology
Original Article
PD-1 protein
Pregnancy
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Summary:Background Throughout the three trimesters of a typical pregnancy, we looked at changes in the expression of miRNAs and exhausted T lymphocytes for this study. Methods and results Fifty healthy subjects were included in this study. The frequency of exhausted T lymphocytes was measured in isolated PBMCs using flow cytometry. PD-1, TIM-3, and related miRNAs gene expression were assessed using qRT-PCR. The analyses revealed a significant decline in PD-1 and Tim-3 expression in PBMCs from RPL women ( p  = 0.0003 and p  = 0.001, respectively). In addition, PD-1 and TIM-3 expression increased significantly in the 2nd trimester compared with the 1st trimester of healthy pregnant women ( p  
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-024-09370-3