Intraoperative mapping and preservation of executive functions in awake craniotomy: a systematic review

• Published in: Neurological sciences 2024-08, Vol.45 (8), p.3723-3735
• Main Authors: Tariq, Rabeet, Aziz, Hafiza Fatima, Paracha, Shahier, Ahmed, Noman, Baqai, Muhammad Waqas Saeed, Bakhshi, Saqib Kamran, McAtee, Annabel, Ainger, Timothy J., Mirza, Farhan A., Enam, Syed Ather
• Format: Article
• Language: English
• Subjects: Brain mapping; Brain Mapping - methods; Brain Neoplasms - surgery; Cognition; Cognitive ability; Craniotomy - adverse effects; Craniotomy - methods; Executive function; Executive Function - physiology; Feasibility studies; Humans; Intraoperative Neurophysiological Monitoring - methods; Medicine; Medicine & Public Health; Neurology; Neuroradiology; Neurosurgery; Preservation; Psychiatry; Quality of life; Review Article; Seizures; Side effects; Systematic review; Wakefulness - physiology
• ISSN: 1590-1874; 1590-3478; 1590-3478
• DOI: 10.1007/s10072-024-07475-y

Awake craniotomy (AC) allows intraoperative brain mapping (ioBM) for maximum lesion resection while monitoring and preserving neurological function. Conventionally, language, visuospatial assessment, and motor functions are mapped, while the assessment of executive functions (EF) is uncommon. Impaired EF may lead to occupational, personal, and social limitations, thus, a compromised quality of life. A comprehensive literature search was conducted through Scopus, Medline, and Cochrane Library using a pre-defined search strategy. Articles were selected after duplicate removal, initial screening, and full-text assessment. The demographic details, ioBM techniques, intraoperative tasks, and their assessments, the extent of resection (EOR), post-op EF and neurocognitive status, and feasibility and potential adverse effects of the procedure were reviewed. The correlations of tumor locations with intraoperative EF deficits were also assessed. A total of 13 studies with intraoperative EF assessment of 351 patients were reviewed. Awake-asleep-awake protocol was most commonly used. Most studies performed ioBM using bipolar stimulation, with a frequency of 60 Hz, pulse durations ranging 1–2 ms, and intensity ranging 2–6 mA. Cognitive function was monitored with the Stroop task, spatial-2-back test, line-bisection test, trail-making-task, and digit-span tests. All studies reported similar or better EOR in patients with ioBM for EF. When comparing the neuropsychological outcomes of patients with ioBM of EF to those without it, all studies reported significantly better EF preservation in ioBM groups. Most authors reported EF mapping as a feasible tool to obtain satisfactory outcomes. Adverse effects included intraoperative seizures which were easily controlled. AC with ioBM of EF is a safe, effective, and feasible technique that allows satisfactory EOR and improved neurocognitive outcomes with minimal adverse effects.