PIRCHE application major versions 3 and 4 lead to equivalent T cell epitope mismatch scores in solid organ and stem cell transplantation modules

PIRCHE scores in organ and stem cell transplantation have been shown to correlate with increased risk of donor-specific HLA antibodies and graft-versus-host disease, respectively. With advancements of the PIRCHE application server, it is critical to compare the predicted scores with previous version...

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Bibliographic Details
Published in:Human immunology 2024-05, Vol.85 (3), p.110789-110789, Article 110789
Main Authors: Matern, Benedict M., Niemann, Matthias
Format: Article
Language:English
Subjects:
Algorithms
Bioinformatics
Epitopes
Epitopes, T-Lymphocyte - immunology
Graft Rejection - diagnosis
Graft Rejection - immunology
Graft vs Host Disease - immunology
Histocompatibility
Histocompatibility Testing - methods
HLA
HLA Antigens - immunology
Humans
Isoantibodies - immunology
Organ Transplantation
Retrospective Studies
Software
Stem Cell Transplantation
Tissue Donors
Transplantation
Validation
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Summary:PIRCHE scores in organ and stem cell transplantation have been shown to correlate with increased risk of donor-specific HLA antibodies and graft-versus-host disease, respectively. With advancements of the PIRCHE application server, it is critical to compare the predicted scores with previous versions. This manuscript compares the newly introduced PIRCHE version 4.2 with its predecessor version 3.3, which was widely used in retrospective studies, using a virtual cohort of 10,000 transplant pairs. In the stem cell transplantation module, both versions yield identical results in 100% of the test population. In the solid organ module, 97% of the test population has identical PIRCHE scores. The deviating cases (3%) were attributed to refinements in the PIRCHE algorithm’s specification. Furthermore, the magnitude of the difference is likely to be below the detection limit for clinical effects, confirming the equivalence in PIRCHE scores between versions 3.3 and 4.2.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2024.110789