Loading…
Neurobehavioral disturbances arising from occupational toluene exposure
Background Neurotoxicity of long‐term exposure to toluene is known at higher levels than 50 ppm and is suspected at lower levels. Methods A cross‐sectional study carried out in two printing plants on 129 blue collar workers explored such a low level exposure of toluene. With 231 samples of ambient a...
Saved in:
| Published in: | American journal of industrial medicine 2002-02, Vol.41 (2), p.77-88 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4550-75c04d4c1b80d69b71539b836e2a518d1db0c3d0da32c0cc0155d5683e7e0e033 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4550-75c04d4c1b80d69b71539b836e2a518d1db0c3d0da32c0cc0155d5683e7e0e033 |
| container_end_page | 88 |
| container_issue | 2 |
| container_start_page | 77 |
| container_title | American journal of industrial medicine |
| container_volume | 41 |
| creator | Chouanière, Dominique Wild, Pascal Fontana, Jean-Marc Héry, Michel Fournier, Maryvonne Baudin, Vincent Subra, Isabelle Rousselle, Dominique Toamain, Jean-Paul Saurin, Sylvie Ardiot, Marie-Rose |
| description | Background
Neurotoxicity of long‐term exposure to toluene is known at higher levels than 50 ppm and is suspected at lower levels.
Methods
A cross‐sectional study carried out in two printing plants on 129 blue collar workers explored such a low level exposure of toluene. With 231 samples of ambient air, toluene concentration was estimated from 0 to 18 ppm in Plant A (offset) and from 2 to 27 ppm in Plant B (heliogravure). Outside any period of acute exposure, the workers answered a self‐administered questionnaire on neurotoxic symptoms, EUROQUEST, and performed six psychometric tests on a computer‐assisted version of battery NES.
Results
After adjustment for confounders, we found significant relationships only between present exposure and Digit Span Forwards (DSF) performance (decrement is 1 digit for 40 ppm, P = 0.04) and Digit Span Backwards (DSB) performance (decrement is 1 digit for 25 ppm, P = 0.01). Neurotoxic symptoms were not significantly correlated with current exposure. No association was found between estimated cumulative exposure and either psychometric performances or neurotoxic symptoms.
Conclusion
In this study, low present exposure levels to toluene were associated with decrements of memory test performances. Am. J. Ind. Med. 41:77–88, 2002. © 2002 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajim.10030 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_29794163</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>18296239</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4550-75c04d4c1b80d69b71539b836e2a518d1db0c3d0da32c0cc0155d5683e7e0e033</originalsourceid><addsrcrecordid>eNqF0cFu1DAQBmALgehSeuEBUC7tASl0xo5j51itylJUWg5F9GY59iy4TeKtvYH27cl2F3qD0_jwzT_Sb8beILxHAH5sb0K_eQl4xmYIjSqBq-o5m00DSyF1vcde5XwDgFjV1Uu2h6hRcOQztrigMcWWftifISbbFT7k9ZhaOzjKhU0hh-F7sUyxL6Jz48quQxwmto7dSAMVdL-KeUz0mr1Y2i7TwW7us68fTq_mH8vzy8XZ_OS8dJWUUCrpoPKVw1aDr5tWoRRNq0VN3ErUHn0LTnjwVnAHzgFK6WWtBSkCAiH22dE2d5Xi3Uh5bfqQHXWdHSiO2fBGNRXW_4eoeVNz0Uzw3Ra6FHNOtDSrFHqbHgyC2fRrNv2ax34n_HaXOrY9-Se6K3QChztgs7PdMk1FhvzkRCV08xiEW_crdPTwj5Pm5NPZ5z_Hy-3O9EV0_3fHpltTK6Gk-XaxMF-Uur6ai7nR4jeROKFE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18296239</pqid></control><display><type>article</type><title>Neurobehavioral disturbances arising from occupational toluene exposure</title><source>Wiley</source><creator>Chouanière, Dominique ; Wild, Pascal ; Fontana, Jean-Marc ; Héry, Michel ; Fournier, Maryvonne ; Baudin, Vincent ; Subra, Isabelle ; Rousselle, Dominique ; Toamain, Jean-Paul ; Saurin, Sylvie ; Ardiot, Marie-Rose</creator><creatorcontrib>Chouanière, Dominique ; Wild, Pascal ; Fontana, Jean-Marc ; Héry, Michel ; Fournier, Maryvonne ; Baudin, Vincent ; Subra, Isabelle ; Rousselle, Dominique ; Toamain, Jean-Paul ; Saurin, Sylvie ; Ardiot, Marie-Rose</creatorcontrib><description>Background
Neurotoxicity of long‐term exposure to toluene is known at higher levels than 50 ppm and is suspected at lower levels.
Methods
A cross‐sectional study carried out in two printing plants on 129 blue collar workers explored such a low level exposure of toluene. With 231 samples of ambient air, toluene concentration was estimated from 0 to 18 ppm in Plant A (offset) and from 2 to 27 ppm in Plant B (heliogravure). Outside any period of acute exposure, the workers answered a self‐administered questionnaire on neurotoxic symptoms, EUROQUEST, and performed six psychometric tests on a computer‐assisted version of battery NES.
Results
After adjustment for confounders, we found significant relationships only between present exposure and Digit Span Forwards (DSF) performance (decrement is 1 digit for 40 ppm, P = 0.04) and Digit Span Backwards (DSB) performance (decrement is 1 digit for 25 ppm, P = 0.01). Neurotoxic symptoms were not significantly correlated with current exposure. No association was found between estimated cumulative exposure and either psychometric performances or neurotoxic symptoms.
Conclusion
In this study, low present exposure levels to toluene were associated with decrements of memory test performances. Am. J. Ind. Med. 41:77–88, 2002. © 2002 Wiley‐Liss, Inc.</description><identifier>ISSN: 0271-3586</identifier><identifier>EISSN: 1097-0274</identifier><identifier>DOI: 10.1002/ajim.10030</identifier><identifier>PMID: 11813212</identifier><identifier>CODEN: AJIMD8</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Air Pollutants, Occupational - adverse effects ; Air Pollutants, Occupational - analysis ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chromatography, Gas ; cognitive ability ; Cross-Sectional Studies ; epidemiology ; EUROQUEST ; Female ; France - epidemiology ; Humans ; Male ; Medical sciences ; Middle Aged ; NES ; Neuropsychological Tests ; neurotoxic symptoms ; Neurotoxicity Syndromes - diagnosis ; Neurotoxicity Syndromes - epidemiology ; Neurotoxicity Syndromes - etiology ; Occupational Diseases - chemically induced ; Occupational Diseases - diagnosis ; Occupational Diseases - epidemiology ; Occupational Exposure - adverse effects ; Occupational Exposure - analysis ; Printing ; psycho-behavioral tests ; Regression Analysis ; Solvents ; Solvents - adverse effects ; Solvents - analysis ; Surveys and Questionnaires ; Time ; toluene ; Toluene - adverse effects ; Toluene - analysis ; Toxicology</subject><ispartof>American journal of industrial medicine, 2002-02, Vol.41 (2), p.77-88</ispartof><rights>Copyright © 2002 Wiley‐Liss, Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4550-75c04d4c1b80d69b71539b836e2a518d1db0c3d0da32c0cc0155d5683e7e0e033</citedby><cites>FETCH-LOGICAL-c4550-75c04d4c1b80d69b71539b836e2a518d1db0c3d0da32c0cc0155d5683e7e0e033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13438930$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11813212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chouanière, Dominique</creatorcontrib><creatorcontrib>Wild, Pascal</creatorcontrib><creatorcontrib>Fontana, Jean-Marc</creatorcontrib><creatorcontrib>Héry, Michel</creatorcontrib><creatorcontrib>Fournier, Maryvonne</creatorcontrib><creatorcontrib>Baudin, Vincent</creatorcontrib><creatorcontrib>Subra, Isabelle</creatorcontrib><creatorcontrib>Rousselle, Dominique</creatorcontrib><creatorcontrib>Toamain, Jean-Paul</creatorcontrib><creatorcontrib>Saurin, Sylvie</creatorcontrib><creatorcontrib>Ardiot, Marie-Rose</creatorcontrib><title>Neurobehavioral disturbances arising from occupational toluene exposure</title><title>American journal of industrial medicine</title><addtitle>Am. J. Ind. Med</addtitle><description>Background
Neurotoxicity of long‐term exposure to toluene is known at higher levels than 50 ppm and is suspected at lower levels.
Methods
A cross‐sectional study carried out in two printing plants on 129 blue collar workers explored such a low level exposure of toluene. With 231 samples of ambient air, toluene concentration was estimated from 0 to 18 ppm in Plant A (offset) and from 2 to 27 ppm in Plant B (heliogravure). Outside any period of acute exposure, the workers answered a self‐administered questionnaire on neurotoxic symptoms, EUROQUEST, and performed six psychometric tests on a computer‐assisted version of battery NES.
Results
After adjustment for confounders, we found significant relationships only between present exposure and Digit Span Forwards (DSF) performance (decrement is 1 digit for 40 ppm, P = 0.04) and Digit Span Backwards (DSB) performance (decrement is 1 digit for 25 ppm, P = 0.01). Neurotoxic symptoms were not significantly correlated with current exposure. No association was found between estimated cumulative exposure and either psychometric performances or neurotoxic symptoms.
Conclusion
In this study, low present exposure levels to toluene were associated with decrements of memory test performances. Am. J. Ind. Med. 41:77–88, 2002. © 2002 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Air Pollutants, Occupational - adverse effects</subject><subject>Air Pollutants, Occupational - analysis</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chromatography, Gas</subject><subject>cognitive ability</subject><subject>Cross-Sectional Studies</subject><subject>epidemiology</subject><subject>EUROQUEST</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>NES</subject><subject>Neuropsychological Tests</subject><subject>neurotoxic symptoms</subject><subject>Neurotoxicity Syndromes - diagnosis</subject><subject>Neurotoxicity Syndromes - epidemiology</subject><subject>Neurotoxicity Syndromes - etiology</subject><subject>Occupational Diseases - chemically induced</subject><subject>Occupational Diseases - diagnosis</subject><subject>Occupational Diseases - epidemiology</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - analysis</subject><subject>Printing</subject><subject>psycho-behavioral tests</subject><subject>Regression Analysis</subject><subject>Solvents</subject><subject>Solvents - adverse effects</subject><subject>Solvents - analysis</subject><subject>Surveys and Questionnaires</subject><subject>Time</subject><subject>toluene</subject><subject>Toluene - adverse effects</subject><subject>Toluene - analysis</subject><subject>Toxicology</subject><issn>0271-3586</issn><issn>1097-0274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqF0cFu1DAQBmALgehSeuEBUC7tASl0xo5j51itylJUWg5F9GY59iy4TeKtvYH27cl2F3qD0_jwzT_Sb8beILxHAH5sb0K_eQl4xmYIjSqBq-o5m00DSyF1vcde5XwDgFjV1Uu2h6hRcOQztrigMcWWftifISbbFT7k9ZhaOzjKhU0hh-F7sUyxL6Jz48quQxwmto7dSAMVdL-KeUz0mr1Y2i7TwW7us68fTq_mH8vzy8XZ_OS8dJWUUCrpoPKVw1aDr5tWoRRNq0VN3ErUHn0LTnjwVnAHzgFK6WWtBSkCAiH22dE2d5Xi3Uh5bfqQHXWdHSiO2fBGNRXW_4eoeVNz0Uzw3Ra6FHNOtDSrFHqbHgyC2fRrNv2ax34n_HaXOrY9-Se6K3QChztgs7PdMk1FhvzkRCV08xiEW_crdPTwj5Pm5NPZ5z_Hy-3O9EV0_3fHpltTK6Gk-XaxMF-Uur6ai7nR4jeROKFE</recordid><startdate>200202</startdate><enddate>200202</enddate><creator>Chouanière, Dominique</creator><creator>Wild, Pascal</creator><creator>Fontana, Jean-Marc</creator><creator>Héry, Michel</creator><creator>Fournier, Maryvonne</creator><creator>Baudin, Vincent</creator><creator>Subra, Isabelle</creator><creator>Rousselle, Dominique</creator><creator>Toamain, Jean-Paul</creator><creator>Saurin, Sylvie</creator><creator>Ardiot, Marie-Rose</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TK</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>200202</creationdate><title>Neurobehavioral disturbances arising from occupational toluene exposure</title><author>Chouanière, Dominique ; Wild, Pascal ; Fontana, Jean-Marc ; Héry, Michel ; Fournier, Maryvonne ; Baudin, Vincent ; Subra, Isabelle ; Rousselle, Dominique ; Toamain, Jean-Paul ; Saurin, Sylvie ; Ardiot, Marie-Rose</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4550-75c04d4c1b80d69b71539b836e2a518d1db0c3d0da32c0cc0155d5683e7e0e033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Air Pollutants, Occupational - adverse effects</topic><topic>Air Pollutants, Occupational - analysis</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chromatography, Gas</topic><topic>cognitive ability</topic><topic>Cross-Sectional Studies</topic><topic>epidemiology</topic><topic>EUROQUEST</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>NES</topic><topic>Neuropsychological Tests</topic><topic>neurotoxic symptoms</topic><topic>Neurotoxicity Syndromes - diagnosis</topic><topic>Neurotoxicity Syndromes - epidemiology</topic><topic>Neurotoxicity Syndromes - etiology</topic><topic>Occupational Diseases - chemically induced</topic><topic>Occupational Diseases - diagnosis</topic><topic>Occupational Diseases - epidemiology</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational Exposure - analysis</topic><topic>Printing</topic><topic>psycho-behavioral tests</topic><topic>Regression Analysis</topic><topic>Solvents</topic><topic>Solvents - adverse effects</topic><topic>Solvents - analysis</topic><topic>Surveys and Questionnaires</topic><topic>Time</topic><topic>toluene</topic><topic>Toluene - adverse effects</topic><topic>Toluene - analysis</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chouanière, Dominique</creatorcontrib><creatorcontrib>Wild, Pascal</creatorcontrib><creatorcontrib>Fontana, Jean-Marc</creatorcontrib><creatorcontrib>Héry, Michel</creatorcontrib><creatorcontrib>Fournier, Maryvonne</creatorcontrib><creatorcontrib>Baudin, Vincent</creatorcontrib><creatorcontrib>Subra, Isabelle</creatorcontrib><creatorcontrib>Rousselle, Dominique</creatorcontrib><creatorcontrib>Toamain, Jean-Paul</creatorcontrib><creatorcontrib>Saurin, Sylvie</creatorcontrib><creatorcontrib>Ardiot, Marie-Rose</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>American journal of industrial medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chouanière, Dominique</au><au>Wild, Pascal</au><au>Fontana, Jean-Marc</au><au>Héry, Michel</au><au>Fournier, Maryvonne</au><au>Baudin, Vincent</au><au>Subra, Isabelle</au><au>Rousselle, Dominique</au><au>Toamain, Jean-Paul</au><au>Saurin, Sylvie</au><au>Ardiot, Marie-Rose</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurobehavioral disturbances arising from occupational toluene exposure</atitle><jtitle>American journal of industrial medicine</jtitle><addtitle>Am. J. Ind. Med</addtitle><date>2002-02</date><risdate>2002</risdate><volume>41</volume><issue>2</issue><spage>77</spage><epage>88</epage><pages>77-88</pages><issn>0271-3586</issn><eissn>1097-0274</eissn><coden>AJIMD8</coden><abstract>Background
Neurotoxicity of long‐term exposure to toluene is known at higher levels than 50 ppm and is suspected at lower levels.
Methods
A cross‐sectional study carried out in two printing plants on 129 blue collar workers explored such a low level exposure of toluene. With 231 samples of ambient air, toluene concentration was estimated from 0 to 18 ppm in Plant A (offset) and from 2 to 27 ppm in Plant B (heliogravure). Outside any period of acute exposure, the workers answered a self‐administered questionnaire on neurotoxic symptoms, EUROQUEST, and performed six psychometric tests on a computer‐assisted version of battery NES.
Results
After adjustment for confounders, we found significant relationships only between present exposure and Digit Span Forwards (DSF) performance (decrement is 1 digit for 40 ppm, P = 0.04) and Digit Span Backwards (DSB) performance (decrement is 1 digit for 25 ppm, P = 0.01). Neurotoxic symptoms were not significantly correlated with current exposure. No association was found between estimated cumulative exposure and either psychometric performances or neurotoxic symptoms.
Conclusion
In this study, low present exposure levels to toluene were associated with decrements of memory test performances. Am. J. Ind. Med. 41:77–88, 2002. © 2002 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11813212</pmid><doi>10.1002/ajim.10030</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-3586 |
| ispartof | American journal of industrial medicine, 2002-02, Vol.41 (2), p.77-88 |
| issn | 0271-3586 1097-0274 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_29794163 |
| source | Wiley |
| subjects | Adult Air Pollutants, Occupational - adverse effects Air Pollutants, Occupational - analysis Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chromatography, Gas cognitive ability Cross-Sectional Studies epidemiology EUROQUEST Female France - epidemiology Humans Male Medical sciences Middle Aged NES Neuropsychological Tests neurotoxic symptoms Neurotoxicity Syndromes - diagnosis Neurotoxicity Syndromes - epidemiology Neurotoxicity Syndromes - etiology Occupational Diseases - chemically induced Occupational Diseases - diagnosis Occupational Diseases - epidemiology Occupational Exposure - adverse effects Occupational Exposure - analysis Printing psycho-behavioral tests Regression Analysis Solvents Solvents - adverse effects Solvents - analysis Surveys and Questionnaires Time toluene Toluene - adverse effects Toluene - analysis Toxicology |
| title | Neurobehavioral disturbances arising from occupational toluene exposure |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T00%3A11%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neurobehavioral%20disturbances%20arising%20from%20occupational%20toluene%20exposure&rft.jtitle=American%20journal%20of%20industrial%20medicine&rft.au=Chouani%C3%A8re,%20Dominique&rft.date=2002-02&rft.volume=41&rft.issue=2&rft.spage=77&rft.epage=88&rft.pages=77-88&rft.issn=0271-3586&rft.eissn=1097-0274&rft.coden=AJIMD8&rft_id=info:doi/10.1002/ajim.10030&rft_dat=%3Cproquest_cross%3E18296239%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4550-75c04d4c1b80d69b71539b836e2a518d1db0c3d0da32c0cc0155d5683e7e0e033%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=18296239&rft_id=info:pmid/11813212&rfr_iscdi=true |