Renal Cell Cancer and Occupational Exposure to Chemical Agents

A case-referent study of occupational risk indicators of renal cell adenocarcinoma was conducted. Each incident case in Finland in 1977—1978 was matched with two population referents. Lifelong job histories were collected and translated into indicators of industry, occupation, and occupational expos...

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Bibliographic Details
Published in:Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 1991-08, Vol.17 (4), p.231-239
Main Authors: PARTGANEN, T, HEIKKILA, P, HERNBERG, S, KAUPPINEN, T, MONETA, G, OJAJARVI, A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Asbestos
Biological and medical sciences
Cadmium
Cancer
Carcinoma, Renal Cell - chemically induced
Case-Control Studies
Female
Finland - epidemiology
Fuel oils
Gasoline
Gasoline - adverse effects
Hazardous Substances - adverse effects
Humans
Kidney cells
Kidney Neoplasms - chemically induced
Kidney Neoplasms - epidemiology
Kidneys
Lead
Lead compounds
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Obesity
Occupational Diseases - chemically induced
Occupations
Prevalence
Referents
Risk Factors
Surveys and Questionnaires
Tumors of the urinary system
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Summary:A case-referent study of occupational risk indicators of renal cell adenocarcinoma was conducted. Each incident case in Finland in 1977—1978 was matched with two population referents. Lifelong job histories were collected and translated into indicators of industry, occupation, and occupational exposures. The analyses of 338 sets of cases and referents revealed elevated risks for a history of employment in white-collar occupations; the printing industry; the chemical industry; the manufacturing of metal products; mail, telephone, and telegraph services; and iron and metal ware work. A decreased risk was observed for male farmers. An elevated risk and an exposure-response relationship were found for gasoline exposure. The excess risk was highest at a latency period of approximately 30 years. The findings support the hypothesis that exposure to some constituent(s) of gasoline increases the incidence of renal adenocarcinoma in humans. Suggestions of elevated risks appeared for exposures to inorganic lead, cadmium, and nonchlorinated solvents.
ISSN:0355-3140
1795-990X
DOI:10.5271/sjweh.1708