The elusive male microbiome: revealing the link between the genital microbiota and fertility. Critical review and future perspectives

• Published in: Critical reviews in clinical laboratory sciences 2024-11, Vol.61 (7), p.559-587
• Main Authors: Jendraszak, Magdalena, Skibińska, Izabela, Kotwicka, Małgorzata, Andrusiewicz, Mirosław
• Format: Article
• Language: English
• Subjects: Fertility; Fertility - physiology; Genitalia, Male - microbiology; Humans; Infertility; Infertility, Male - microbiology; Male; Male reproductive system; Microbiota; Microbiota - physiology
• ISSN: 1040-8363; 1549-781X; 1549-781X
• DOI: 10.1080/10408363.2024.2331489

There is a growing focus on understanding the role of the male microbiome in fertility issues. Although research on the bacterial communities within the male reproductive system is in its initial phases, recent discoveries highlight notable variations in the microbiome's composition and abundance across distinct anatomical regions like the skin, foreskin, urethra, and coronary sulcus. To assess the relationship between male genitourinary microbiome and reproduction, we queried various databases, including MEDLINE (available PubMed), SCOPUS, and Web of Science to obtain evidence-based data. The literature search was conducted using the following terms "gut/intestines microbiome," "genitourinary system microbiome," "microbiome and female/male infertility," "external genital tract microbiome," "internal genital tract microbiome," and "semen microbiome." Fifty-one relevant papers were analyzed, and eleven were strictly semen quality or male fertility related. The male microbiome, especially in the accessory glands like the prostate, seminal vesicles, and bulbourethral glands, has garnered significant interest because of its potential link to male fertility and reproduction. Studies have also found differences in bacterial diversity present in the testicular tissue of normozoospermic men compared to azoospermic suggesting a possible role of bacterial dysbiosis and reproduction. Correlation between the bacterial taxa in the genital microbiota of sexual partners has also been found, and sexual activity can influence the composition of the urogenital microbiota. Exploring the microbial world within the male reproductive system and its influence on fertility opens doors to developing ways to prevent, diagnose, and treat infertility. The present work emphasizes the importance of using consistent methods, conducting long-term studies, and deepening our understanding of how the reproductive tract microbiome works. This helps make research comparable, pinpoint potential interventions, and smoothly apply microbiome insights to real-world clinical practices.