Preparation and characterisation of controlled porosity alginate hydrogels made via a simultaneous micelle templating and internal gelation process

Controlled porosity alginate hydrogel monoliths were synthesised by simultaneous micelle templating (MT) and an internal gelation reaction. In water, the self assembling surfactant, cetyltrimethylammonium bromide (CTAB) formed non-spherical micelles that were used as a template for pore formation. T...

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Bibliographic Details
Published in:Journal of materials science 2007-05, Vol.42 (10), p.3502-3507
Main Authors: PARTAP, S, MUTHUTANTRI, A, REHMAN, I. U, DAVIS, G. R, DARR, J. A
Format: Article
Language:English
Subjects:
Alginates
Cetyltrimethylammonium bromide
Chemistry
Colloidal gels. Colloidal sols
Colloidal state and disperse state
Compression tests
Ethanol
Ethyl alcohol
Exact sciences and technology
Fourier transforms
Gelation
General and physical chemistry
Helium
Hydrogels
Intrusion
Materials science
Micelles
Micelles. Thin films
Pore formation
Pore size
Porosity
Porous materials
Pycnometry
Scanning electron microscopy
Surfactants
Tissue engineering
X ray microtomography
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Summary:Controlled porosity alginate hydrogel monoliths were synthesised by simultaneous micelle templating (MT) and an internal gelation reaction. In water, the self assembling surfactant, cetyltrimethylammonium bromide (CTAB) formed non-spherical micelles that were used as a template for pore formation. The porous microstructure was assessed by mercury intrusion porosimetry (MIP), helium pycnometry, X-ray microtomography (XMT) and scanning electron microscopy (SEM), respectively. The MT hydrogels displayed relatively monodisperse pore size distributions (with pore sizes ranging from 32.5 μm to 164.0 μm), high total pore volumes (4.5–20.3 cm3/g) and high degrees of porosity (83–97%). Some control over pore size distributions was achieved by varying the surfactant concentration; higher surfactant concentrations, led to smaller pores with lower total pore volumes. Uniaxial compression testing revealed that hydrogels made via MT are stable in cell culture media for 28 days. Fourier transform infrared (FTIR) spectroscopy data, suggested that all surfactant could be removed from the final product by washing with ethanol and water, making these hydrogels potentially suitable for tissue engineering (TE) applications.
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-007-1533-x