Preparation and characterization of biodegradable magnetic carriers by single emulsion-solvent evaporation

This paper describes a single emulsion-solvent evaporation protocol to prepare PEGylated biodegradable/biocompatible magnetic carriers by utilizing hydrophobic magnetite and a mixture of poly( D,L lactide-co-glycolide) (PLGA) and poly(lactic acid-block-polyethylene glycol) (PLA-PEG) (26:1 by mass) p...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2007-04, Vol.311 (1), p.84-87
Main Authors: Liu, Xianqiao, Kaminski, Michael D., Riffle, Judy S., Chen, Haitao, Torno, Michael, Finck, Martha R., Taylor, LaToyia, Rosengart, Axel J.
Format: Article
Language:English
Subjects:
Biodegradable
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Exact sciences and technology
Magnetic carrier
Magnetic properties and materials
Magnetic properties of nanostructures
Magnetic target drug delivery
Magnetite
Physics
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Summary:This paper describes a single emulsion-solvent evaporation protocol to prepare PEGylated biodegradable/biocompatible magnetic carriers by utilizing hydrophobic magnetite and a mixture of poly( D,L lactide-co-glycolide) (PLGA) and poly(lactic acid-block-polyethylene glycol) (PLA-PEG) (26:1 by mass) polymers. We characterized the magnetic microspheres in terms of morphology, composite microstructure, size and size distribution, and magnetic properties. Results show that the preparation produces magnetic microspheres with a good spherical morphology, small size (mean diameter of 1.2–1.5 μm) by means of large size distributions, and magnetizations up to 20–30 emu/g of microspheres.
ISSN:0304-8853
DOI:10.1016/j.jmmm.2006.10.1170