Optical coherence tomography of malignancy in hamster cheek pouches

Optical coherence tomography (OCT)/optical Doppler tomography (ODT) provides real-time high-resolution (10- m) imaging of tissues and real-time spatially resolved blood flow in microvasculature. Hamster cheek pouches with induced dysplasia and malignancies were imaged with OCT/ODT to assess the pote...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2004-09, Vol.9 (5), p.978-981
Main Authors: Matheny, Erin S, Hanna, Nevine M, Jung, W. G, Chen, Zhongping, Wilder-Smith, Petra, Mina-Araghi, Reza, Brenner, Matthew
Format: Article
Language:English
Subjects:
9,10-Dimethyl-1,2-benzanthracene
airway injury
Animals
Cricetinae
diagnostic
laser
malignant
Mesocricetus
Mouth Neoplasms - chemically induced
Mouth Neoplasms - pathology
oral cancer
Reproducibility of Results
Sensitivity and Specificity
Single-Blind Method
Tomography, Optical Coherence - methods
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Summary:Optical coherence tomography (OCT)/optical Doppler tomography (ODT) provides real-time high-resolution (10- m) imaging of tissues and real-time spatially resolved blood flow in microvasculature. Hamster cheek pouches with induced dysplasia and malignancies were imaged with OCT/ODT to assess the potential for application to airway malignancy. In 22 Golden Syrian hamsters, 0.5 9,10-dimethyl-1,2-benzanthracene induces carcinogenesis over 10 weeks in right side cheek pouches; the left side three served as controls. The cheek pouches are imaged prior to sacrifice, and after excision, using a prototype 1310-nm broadband superluminescent diode based OCT/ODT device. Images are compared to standard histopathology. OCT imaging offers good resolution of the hamster cheek pouches to depths of 1 to 3 mm and paralleled histologic images. The feasibility of high-resolution functional imaging is demonstrated in this hamster cheek pouch tumor model. ODT accurately detects vascular change associated with carcinogenesis. ©
ISSN:1083-3668
1560-2281
DOI:10.1117/1.1783897