Reactive polymeric nanoparticles based on unconventional dextran derivatives

Unconventional dextran derivatives with reactive tosyl- and deoxy-azido moieties were synthesized homogeneously under various reaction conditions. Well soluble tosyl dextran of a high degree of substitution up to 1.66 was prepared applying N, N-dimethylacetamide/LiCl as solvent. Almost 50% of second...

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Bibliographic Details
Published in:European polymer journal 2007-03, Vol.43 (3), p.697-703
Main Authors: Heinze, Th, Michealis, N., Hornig, St
Format: Article
Language:English
Subjects:
Applied sciences
Deoxy-azido dextran
Dextran
Exact sciences and technology
Nanoparticles
Natural polymers
Physicochemistry of polymers
Polysaccharide
Starch and polysaccharides
Synthesis
Tosyl dextran
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Summary:Unconventional dextran derivatives with reactive tosyl- and deoxy-azido moieties were synthesized homogeneously under various reaction conditions. Well soluble tosyl dextran of a high degree of substitution up to 1.66 was prepared applying N, N-dimethylacetamide/LiCl as solvent. Almost 50% of secondary toslyate moieties could be replaced by nucleophilic displacement reaction with azide ions. The structure of the products was efficiently analyzed by NMR spectroscopy also after peracylation of the unconventional dextran derivatives. Applying a simple dialysis technique, nanospheres with a size in the range from 160 to 420 nm (D50%) were obtained that possess reactive functional tosyl- and deoxy-azido groups.
ISSN:0014-3057
1873-1945
DOI:10.1016/j.eurpolymj.2006.12.009