Study on compatibility of imatinib mesylate with pharmaceutical excipients

Differential scanning calorimetry and thermogravimetric analysis with the support of X-ray powder diffraction and infrared spectroscopy were used as screening techniques for the compatibility testing of imatinib mesylate, with following excipients: magnesium stearate, polyvinylpyrrolidone, microcrys...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2007-05, Vol.88 (2), p.305-310
Main Authors: ŁASZCZ, M, KOSMACINSKA, B, KORCZAK, K, SMIGIELSKA, B, GLICE, M, MARUSZAK, W, GROMAN, A, BECZKOWICZ, H, ZELAZKO, L
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Summary:Differential scanning calorimetry and thermogravimetric analysis with the support of X-ray powder diffraction and infrared spectroscopy were used as screening techniques for the compatibility testing of imatinib mesylate, with following excipients: magnesium stearate, polyvinylpyrrolidone, microcrystalline cellulose. In order to maximize the probability of interactions 1:1 (by mass) drug: excipient binary mixtures were analysed and compared to individual components. Additionally an influence of storage at temperatures of 25 and 40 deg C on physico-chemical stability on drug - excipient binary mixtures was investigated.
ISSN:1388-6150
1588-2926
DOI:10.1007/s10973-006-8001-8