Comparative study of some nano- and micro - sensitizers in photodynamic inactivation of microorganisms

The development of new virus inactivation procedures became an area of growing interest mainly due to increased demands concerning the safety of biological products. Photochemical processes represent the most promising methods for the future to inactivate viruses. In these methods, dyes are the most...

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Bibliographic Details
Published in:Journal of Optoelectronics and Advanced Materials 2007-06, Vol.9 (6), p.1933-1938
Main Authors: Ion, R M, Calin, M A
Format: Article
Language:English
Online Access:Get full text
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Summary:The development of new virus inactivation procedures became an area of growing interest mainly due to increased demands concerning the safety of biological products. Photochemical processes represent the most promising methods for the future to inactivate viruses. In these methods, dyes are the most widely used photosensitising reagents. The current article covers a new interesting compound microsensitizer as 5,10,15,20-tetra-sulfonato-phenyl porphyrin (TSPP), and nanosensitizers, as fullerenes (C60) -coated TSPP suspension (C60/TSPP). There was studied in this paper the photodynamic inactivation of herpes simplex virus type I (HSV-1) provided from rat, by the above macro and nano-sensitizers. The concentration and temperature effects were evaluated. These sensitizers demonstrate a remarkable virucidal activity upon light activation, more pronounced for (C60/TSPP) than for TSPP, and after an optimum time of 300 minutes.
ISSN:1454-4164