Modified polycarbonate urethane: Synthesis, properties and biological investigation in vitro

A new polycarbonate urethane (PCU‐I) was synthesized from aliphatic monomers, i.e. polyhexamethylene carbonate diol and 4,4′‐methylene‐bis cyclohexane diisocyanate, a mixture of low molecular diols, and castor oil (containing mainly the triglyceride of 12‐hydroxyoleic acid). The second synthesized p...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2007-08, Vol.82A (2), p.509-520
Main Authors: Szelest-Lewandowska, A., Masiulanis, B., Szymonowicz, M., Pielka, S., Paluch, D.
Format: Article
Language:English
Subjects:
Animals
BALB 3T3 Cells
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biocompatible Materials - toxicity
Blood Coagulation - drug effects
cytotoxicity
Drug Stability
hemocompatibility
Hemolysis - drug effects
Humans
In Vitro Techniques
Materials Testing
Mice
modified polycarbonate urethane
physical properties
Polycarboxylate Cement - chemical synthesis
Polycarboxylate Cement - chemistry
Polycarboxylate Cement - toxicity
Polyurethanes - chemical synthesis
Polyurethanes - chemistry
Polyurethanes - toxicity
resistance to sterilization
Sterilization
Tensile Strength
Thermodynamics
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Summary:A new polycarbonate urethane (PCU‐I) was synthesized from aliphatic monomers, i.e. polyhexamethylene carbonate diol and 4,4′‐methylene‐bis cyclohexane diisocyanate, a mixture of low molecular diols, and castor oil (containing mainly the triglyceride of 12‐hydroxyoleic acid). The second synthesized polymer (PCU‐II) did not contain castor oil. Both PCUs had good tensile strength, i.e. 32.5 and 27.8 MPa for PCU‐I and PCU‐II, respectively. Modification by castor oil led to a decrease in glass transition temperature (Tg = −14°C for PCU‐I and −6°C for PCU‐II) and an increase in the softening temperature (135 and 125°C for PCU‐I and PCU‐II, respectively). Partial crosslinking of PCU‐I increased the storage modulus of elasticity and provided better resistance to sterilization by ETO and γ radiation. Both PCUs displayed good stability when subjected to sterilization by hydrogen peroxide plasma. Neither PCU caused cytotoxic effect in mouse fibroblasts (3T3 Balb C). They also had no toxic effects on the morphotic components and did not influence changes in the hematologic parameters or plasmatic coagulation system of human blood. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2007
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.31357