Vaccine Biotechnology by Accelerated Electron Beam and Microwave Irradiation

A new biotechnology for obtaining a commercial vaccine that contains either Fusobacterium necrophorum (F.n.) exotoxins inactivated by accelerated electron beam (EB) and microwave (MW) irradiation, or exotoxins isolated from F.n. cultures irradiated with EB+MW, is presented. This vaccine is designed...

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Bibliographic Details
Main Authors: Craciun, Gabriela D, Togoe, Iulian I, Tudor, Laurentiu M, Martin, Diana I, Manaila, Elena N, Ighigeanu, Daniel I, Iacob, Nicusor I, Oproiu, Constantin V
Format: Conference Proceeding
Language:English
Online Access:Get full text
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Summary:A new biotechnology for obtaining a commercial vaccine that contains either Fusobacterium necrophorum (F.n.) exotoxins inactivated by accelerated electron beam (EB) and microwave (MW) irradiation, or exotoxins isolated from F.n. cultures irradiated with EB+MW, is presented. This vaccine is designed for prophylaxis of ruminant infectious pododermatitis (IP) produced by F.n. Also, the research results concerning the effects of combined chemical adjuvant and EB+MW irradiation on F.n. immune capacity are discussed. The vaccine's efficacy will be tested in ruminant farms in which IP evolves. It is expected that this new vaccine to offer a better protection, more than 60%, which is the best presently obtained result in ruminant farms.
ISSN:0094-243X
DOI:10.1063/1.2733510