Inubritantrimers A–D: Trimerized Sesquiterpenoid [4 + 2] Adducts Featuring a Distinctive Spiro-Polycyclic Scaffold from Inula britannica

Inubritantrimer A (1), a trace trimerized sesquiterpenoid [4 + 2] adduct featuring an unusual exo-exo type spiro-polycyclic scaffold, together with three new endo-exo [4 + 2] adducts, inubritantrimers B–D (2–4), were discovered from the flowers of Inula britannica. Their structures were elucidated u...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-04, Vol.89 (7), p.5029-5037
Main Authors: Guo, Cong, Qi, Ruo-Yu, Ren, Jie-Yi, Xu, Dan-Dan, Zhang, Qiang, Gao, Jin-Ming, Tang, Jiang-Jiang
Format: Article
Language:English
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Summary:Inubritantrimer A (1), a trace trimerized sesquiterpenoid [4 + 2] adduct featuring an unusual exo-exo type spiro-polycyclic scaffold, together with three new endo-exo [4 + 2] adducts, inubritantrimers B–D (2–4), were discovered from the flowers of Inula britannica. Their structures were elucidated using 1D/2D NMR, X-ray diffraction, and ECD approaches. 1 is characterized as a novel exo-exo trimer, synthesized biogenetically from three sesquiterpenoid monomers, featuring a unique linkage of C-11/C-1′, C-13/C-3′ and C-13′/C-3″, C-11′/C-1″ through a two-step exo [4 + 2] cycloaddition process. Compounds 1–4 exhibited modest cytotoxicity against breast cancer cells with IC50 values in the range of 5.84–12.01 μM.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.4c00248