Preparation and characterization of polycaprolactone-chitosan composites for tissue engineering applications

Highly porous scaffold plays an important role in bone tissue engineering, which becomes a promising alternative approach for bone repair since its emergence. The objective of this work was to blend poly (є-caprolactone) (PCL) with chitosan (CS) for the purpose of preparation of porous scaffold. A s...

Full description

Saved in:
Bibliographic Details
Published in:Journal of materials science 2007-10, Vol.42 (19), p.8113-8119
Main Authors: She, Houde, Xiao, Xiufeng, Liu, Rongfang
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Chitosan
Composite materials
Exact sciences and technology
Forms of application and semi-finished materials
Fractures
Materials science
Medical sciences
Miscellaneous
Miscibility
Morphology
Phase separation
Polycaprolactone
Polymer industry, paints, wood
Porosity
Scaffolds
Structural damage
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology of polymers
Technology. Biomaterials. Equipments
Tissue engineering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highly porous scaffold plays an important role in bone tissue engineering, which becomes a promising alternative approach for bone repair since its emergence. The objective of this work was to blend poly (є-caprolactone) (PCL) with chitosan (CS) for the purpose of preparation of porous scaffold. A simple unique method was employed under room-temperature condition to blend the two components together without separation of two phases. The reaction leads to formation of sponge-like porous 5, 10, 15 and 20 wt% CS composites. XRD, IR and SEM were used to determine components and morphology of the composites. DSC studies indicated that the miscibility of the two components. And pore volume fractures of composites were determined by a simple method in which a pycnometer was used. The results show that CS is successfully commingled into PCL matrix, and adding CS into PCL will not damage the crystalline structure of PCL. The composite shows no signs of phase separation and presents a unique porous structure under SEM observation. The porosity of composite increased with the increase of the content of CS in the composite. The highest porosity reached to 92% when CS content increased to 20 wt%. The mechanism of formation of this unique porous structure is also discussed.
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-007-1706-7