Plasma-sprayed carbon nanotube reinforced hydroxyapatite coatings and their interaction with human osteoblasts in vitro

Abstract Carbon nanotubes (CNT) possess excellent mechanical properties to play the role as reinforcement for imparting strength and toughness to brittle hydroxyapatite (HA) bioceramic coating. However, lack of processing technique to uniformly distribute multiwalled CNTs in HA coating and limited s...

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Bibliographic Details
Published in:Biomaterials 2007-02, Vol.28 (4), p.618-624
Main Authors: Balani, Kantesh, Anderson, Rebecca, Laha, Tapas, Andara, Melanie, Tercero, Jorge, Crumpler, Eric, Agarwal, Arvind
Format: Article
Language:English
Subjects:
Advanced Basic Science
Calcification, Physiologic
Carbon nanotube (CNT)
Cell Line
Cell Proliferation
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - metabolism
Crystallinity
Crystallization
Dentistry
Durapatite - chemistry
Durapatite - metabolism
Human osteoblast
Humans
Hydroxyapatite coating
Materials Testing
Microscopy, Electron, Scanning
Nanotubes, Carbon - chemistry
Nanotubes, Carbon - ultrastructure
Osteoblasts - cytology
Osteoblasts - metabolism
Plasma spraying
Stress, Mechanical
Titanium alloy
X-Ray Diffraction
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Summary:Abstract Carbon nanotubes (CNT) possess excellent mechanical properties to play the role as reinforcement for imparting strength and toughness to brittle hydroxyapatite (HA) bioceramic coating. However, lack of processing technique to uniformly distribute multiwalled CNTs in HA coating and limited studies and sparse knowledge evincing toxicity of CNTs has kept researchers in dispute for long. In the current work, we have addressed these issues by (i) successfully distributing multiwalled CNT reinforcement in HA coating using plasma spraying to improve the fracture toughness (by 56%) and enhance crystallinity (by 27%), and (ii) culturing human osteoblast hFOB 1.19 cells onto CNT reinforced HA coating to elicit its biocompatibility with living cells. Unrestricted growth of human osteoblast hFOB 1.19 cells has been observed near CNT regions claiming assistance by CNT surfaces to promote cell growth and proliferation.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2006.09.013