The Effect of Surgical Procedure in the Nasal Cavity on the Passive Avoidance Conditioning and the Hypothalamic Level of Monoamines in Rats

A rat biological model of septoplasty was used to study the effect of surgery on passive avoidance conditioning (PAC). Septoplasty was shown to increase anxiety and to reduce exploratory activity in rodents during PAC. A neurochemical analysis of the hypothalamus was carried out immediately after th...

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Bibliographic Details
Published in:Doklady. Biological sciences 2024-06, Vol.516 (1), p.27-31
Main Authors: Korolev, A. G., Kastyro, I. V., Inozemtsev, A. N., Latanov, A. V.
Format: Article
Language:English
Subjects:
Animals
Avoidance Learning - physiology
Biomedical and Life Sciences
Evolutionary Biology
Exploratory behavior
Hypothalamic-pituitary-adrenal axis
Hypothalamo-Hypophyseal System - metabolism
Hypothalamus
Hypothalamus - metabolism
Life Sciences
Male
Monoamines
Nasal Cavity - metabolism
Nasal Cavity - surgery
Nasal Septum - metabolism
Nasal Septum - surgery
Norepinephrine
Norepinephrine - metabolism
Nose
Pituitary
Plant Sciences
Rats
Rats, Wistar
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Summary:A rat biological model of septoplasty was used to study the effect of surgery on passive avoidance conditioning (PAC). Septoplasty was shown to increase anxiety and to reduce exploratory activity in rodents during PAC. A neurochemical analysis of the hypothalamus was carried out immediately after the end of the experiment and showed an increase in norepinephrine (NE) metabolism after septoplasty. The finding was tentatively associated with activation of the hypothalamic-pituitary-adrenal axis.
ISSN:0012-4966
1608-3105
DOI:10.1134/S0012496624700959